Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential

Ken Kataoka; Akinori Nakajima; Yoshimi Takata; Shigeru Saito; Nam ho Huh

doi:10.1016/S0304-3835(00)00685-6

Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential

Ken Kataoka, Akinori Nakajima, Yoshimi Takata, Shigeru Saito, Nam ho Huh^*

^*Corresponding author for this work

Member of the Board

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

During the formation of placenta, trophoblast cells vigorously invade maternal uterine tissues, sharing many features with the invasion of cancers. We applied RNA differential display to placenta tissues from 8.5 to 17.5 days post-coitus (dpc) ICR mice, and isolated 188 cDNA fragments expressed differentially. Among the 25 known cDNA fragments thus far analyzed, six cDNAs have been reported to be relevant to tumor invasion and/or metastasis. Furthermore, 11 of 20 unknown cDNAs isolated showed differential expression between the pairs of cancer cell lines with low and high metastatic potential, indicating potential usefulness of the present two-step approach.

Original language	English
Pages (from-to)	213-219
Number of pages	7
Journal	Cancer Letters
Volume	163
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00685-6
State	Published - 2001/02/26

Keywords

Cancer cell lines
Differential display
Gene
Metastasis
Placenta

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0304-3835(00)00685-6

Cite this

@article{62e4a42aecda404885a8b1fc9cf7bd67,

title = "Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential",

abstract = "During the formation of placenta, trophoblast cells vigorously invade maternal uterine tissues, sharing many features with the invasion of cancers. We applied RNA differential display to placenta tissues from 8.5 to 17.5 days post-coitus (dpc) ICR mice, and isolated 188 cDNA fragments expressed differentially. Among the 25 known cDNA fragments thus far analyzed, six cDNAs have been reported to be relevant to tumor invasion and/or metastasis. Furthermore, 11 of 20 unknown cDNAs isolated showed differential expression between the pairs of cancer cell lines with low and high metastatic potential, indicating potential usefulness of the present two-step approach.",

keywords = "Cancer cell lines, Differential display, Gene, Metastasis, Placenta",

author = "Ken Kataoka and Akinori Nakajima and Yoshimi Takata and Shigeru Saito and Huh, {Nam ho}",

note = "Funding Information: This work was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan. We sincerely thank Professor Ikuo Saiki for providing cell lines, and Dr Mikiro Takaishi for his technical support and critical reading of the manuscript.",

year = "2001",

month = feb,

day = "26",

doi = "10.1016/S0304-3835(00)00685-6",

language = "英語",

volume = "163",

pages = "213--219",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential

AU - Kataoka, Ken

AU - Nakajima, Akinori

AU - Takata, Yoshimi

AU - Saito, Shigeru

AU - Huh, Nam ho

N1 - Funding Information: This work was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan. We sincerely thank Professor Ikuo Saiki for providing cell lines, and Dr Mikiro Takaishi for his technical support and critical reading of the manuscript.

PY - 2001/2/26

Y1 - 2001/2/26

N2 - During the formation of placenta, trophoblast cells vigorously invade maternal uterine tissues, sharing many features with the invasion of cancers. We applied RNA differential display to placenta tissues from 8.5 to 17.5 days post-coitus (dpc) ICR mice, and isolated 188 cDNA fragments expressed differentially. Among the 25 known cDNA fragments thus far analyzed, six cDNAs have been reported to be relevant to tumor invasion and/or metastasis. Furthermore, 11 of 20 unknown cDNAs isolated showed differential expression between the pairs of cancer cell lines with low and high metastatic potential, indicating potential usefulness of the present two-step approach.

AB - During the formation of placenta, trophoblast cells vigorously invade maternal uterine tissues, sharing many features with the invasion of cancers. We applied RNA differential display to placenta tissues from 8.5 to 17.5 days post-coitus (dpc) ICR mice, and isolated 188 cDNA fragments expressed differentially. Among the 25 known cDNA fragments thus far analyzed, six cDNAs have been reported to be relevant to tumor invasion and/or metastasis. Furthermore, 11 of 20 unknown cDNAs isolated showed differential expression between the pairs of cancer cell lines with low and high metastatic potential, indicating potential usefulness of the present two-step approach.

KW - Cancer cell lines

KW - Differential display

KW - Gene

KW - Metastasis

KW - Placenta

UR - http://www.scopus.com/inward/record.url?scp=0035952368&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(00)00685-6

DO - 10.1016/S0304-3835(00)00685-6

M3 - 学術論文

C2 - 11165757

AN - SCOPUS:0035952368

SN - 0304-3835

VL - 163

SP - 213

EP - 219

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this