Ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes with amines: Rapid access to 2-substituted 4-hydroxyindole

Keyphrases

• Amines 100%
• 2-substituted 100%
• Spirocyclopropane 100%
• 1,3-Cyclohexanedione 100%
• Ring-opening Cyclizations 100%
• Hydroxyindole 100%
• Rapid Access 100%
• Room Temperature 33%
• Excellent Yields 33%
• Primary Amines 33%
• Indoline 33%

Chemistry

• Ring Opening Reaction 100%
• cyclohexane-1,3-dione 100%
• 4-Hydroxyindole 100%
• Ambient Reaction Temperature 50%
• Primary Amine 50%
• Indolines 50%
• formation 50%