Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: Involvement of N-methyl-D-aspartate receptor

Kazue Takahata; Hiroshi Katsuki; Toshiaki Kume; Ken Ito; Yoshinaga Tochikawa; Shizuko Muraoka; Fumio Yoneda; Satoshi Kashii; Yoshihito Honda; Akinori Akaike

doi:10.1254/jphs.92.428

Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: Involvement of N-methyl-D-aspartate receptor

Kazue Takahata, Hiroshi Katsuki, Toshiaki Kume, Ken Ito, Yoshinaga Tochikawa, Shizuko Muraoka, Fumio Yoneda, Satoshi Kashii, Yoshihito Honda, Akinori Akaike^*

^*Corresponding author for this work

Applied Pharmacology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-D-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO-glutamate receptor in several ophthalmic disorders.

Original language	English
Pages (from-to)	428-432
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	92
Issue number	4
DOIs	https://doi.org/10.1254/jphs.92.428
State	Published - 2003/08/01

Keywords

Neurodegeneration
Nitric oxide
Retina

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.92.428

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title = "Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: Involvement of N-methyl-D-aspartate receptor",

abstract = "We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-D-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO-glutamate receptor in several ophthalmic disorders.",

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author = "Kazue Takahata and Hiroshi Katsuki and Toshiaki Kume and Ken Ito and Yoshinaga Tochikawa and Shizuko Muraoka and Fumio Yoneda and Satoshi Kashii and Yoshihito Honda and Akinori Akaike",

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AU - Takahata, Kazue

AU - Katsuki, Hiroshi

AU - Kume, Toshiaki

AU - Ito, Ken

AU - Tochikawa, Yoshinaga

AU - Muraoka, Shizuko

AU - Yoneda, Fumio

AU - Kashii, Satoshi

AU - Honda, Yoshihito

AU - Akaike, Akinori

PY - 2003/8/1

Y1 - 2003/8/1

N2 - We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-D-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO-glutamate receptor in several ophthalmic disorders.

AB - We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-D-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO-glutamate receptor in several ophthalmic disorders.

KW - Neurodegeneration

KW - Nitric oxide

KW - Retina

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Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: Involvement of N-methyl-D-aspartate receptor

Abstract

Keywords

ASJC Scopus subject areas

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