Research of ginsenosides in Kou zi qi using HPLC-MS-MS

Kun Zou; Zhao Xia Liu; Shu Zhu; Shao Qing Cai; Katsuko Komatsu

Research of ginsenosides in Kou zi qi using HPLC-MS-MS

Kun Zou^*, Zhao Xia Liu, Shu Zhu, Shao Qing Cai, Katsuko Komatsu

^*Corresponding author for this work

Section of Pharmacognosy, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Aim: To analyze the ginsenosides in Kou zi qi (rhizomes of Panax japonicus C. A. Mey. var. major (Burkill) C. Y. Wu et K. M. Feng), and to supply evidences for chemotaxanology of Panax species and clinical uses of Kou zi qi. Methods: The ginsenosides were isolated by HPLC, then the positive- and negative-ion API-MS/MS of constituents collected from HPLC were measured. Results: Eight ginsenosides were identified as ginsenoside Re, ginsenoside Ro, chikuseksusaponins IV, IVa, notoginsenoside R₂, ginsenosides Rb ₁, Rc and Rd, respectively, based on comparison of retention time with those of standards by HPLC, and analysis on their API-MS/MS data. Ginsenoside Ro and chikuseksusaponin IVa are the major components of Kou zi qi. Conclusion: This plant had a close relationship to P. stipuleanatus, P. zinginensis and P. japonicus var major; a relatively remote relationship to P. ginseng and P. quinquefolius, in a view of chemotaxanology. Ginsenoside Ro and chikuseksusaponin IVa might be the anti-inflammatory constituents of Kou zi qi.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	Yaoxue Xuebao
Volume	39
Issue number	5
State	Published - 2004/05

Keywords

Ginsenosides
Kou zi qi
Panax

ASJC Scopus subject areas

Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics

Cite this

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title = "Research of ginsenosides in Kou zi qi using HPLC-MS-MS",

abstract = "Aim: To analyze the ginsenosides in Kou zi qi (rhizomes of Panax japonicus C. A. Mey. var. major (Burkill) C. Y. Wu et K. M. Feng), and to supply evidences for chemotaxanology of Panax species and clinical uses of Kou zi qi. Methods: The ginsenosides were isolated by HPLC, then the positive- and negative-ion API-MS/MS of constituents collected from HPLC were measured. Results: Eight ginsenosides were identified as ginsenoside Re, ginsenoside Ro, chikuseksusaponins IV, IVa, notoginsenoside R2, ginsenosides Rb 1, Rc and Rd, respectively, based on comparison of retention time with those of standards by HPLC, and analysis on their API-MS/MS data. Ginsenoside Ro and chikuseksusaponin IVa are the major components of Kou zi qi. Conclusion: This plant had a close relationship to P. stipuleanatus, P. zinginensis and P. japonicus var major; a relatively remote relationship to P. ginseng and P. quinquefolius, in a view of chemotaxanology. Ginsenoside Ro and chikuseksusaponin IVa might be the anti-inflammatory constituents of Kou zi qi.",

keywords = "Ginsenosides, Kou zi qi, Panax",

author = "Kun Zou and Liu, {Zhao Xia} and Shu Zhu and Cai, {Shao Qing} and Katsuko Komatsu",

year = "2004",

month = may,

language = "英語",

volume = "39",

pages = "385--388",

journal = "Yaoxue Xuebao",

issn = "0513-4870",

publisher = "Chinese Pharmaceutical Association",

number = "5",

}

TY - JOUR

T1 - Research of ginsenosides in Kou zi qi using HPLC-MS-MS

AU - Zou, Kun

AU - Liu, Zhao Xia

AU - Zhu, Shu

AU - Cai, Shao Qing

AU - Komatsu, Katsuko

PY - 2004/5

Y1 - 2004/5

N2 - Aim: To analyze the ginsenosides in Kou zi qi (rhizomes of Panax japonicus C. A. Mey. var. major (Burkill) C. Y. Wu et K. M. Feng), and to supply evidences for chemotaxanology of Panax species and clinical uses of Kou zi qi. Methods: The ginsenosides were isolated by HPLC, then the positive- and negative-ion API-MS/MS of constituents collected from HPLC were measured. Results: Eight ginsenosides were identified as ginsenoside Re, ginsenoside Ro, chikuseksusaponins IV, IVa, notoginsenoside R2, ginsenosides Rb 1, Rc and Rd, respectively, based on comparison of retention time with those of standards by HPLC, and analysis on their API-MS/MS data. Ginsenoside Ro and chikuseksusaponin IVa are the major components of Kou zi qi. Conclusion: This plant had a close relationship to P. stipuleanatus, P. zinginensis and P. japonicus var major; a relatively remote relationship to P. ginseng and P. quinquefolius, in a view of chemotaxanology. Ginsenoside Ro and chikuseksusaponin IVa might be the anti-inflammatory constituents of Kou zi qi.

AB - Aim: To analyze the ginsenosides in Kou zi qi (rhizomes of Panax japonicus C. A. Mey. var. major (Burkill) C. Y. Wu et K. M. Feng), and to supply evidences for chemotaxanology of Panax species and clinical uses of Kou zi qi. Methods: The ginsenosides were isolated by HPLC, then the positive- and negative-ion API-MS/MS of constituents collected from HPLC were measured. Results: Eight ginsenosides were identified as ginsenoside Re, ginsenoside Ro, chikuseksusaponins IV, IVa, notoginsenoside R2, ginsenosides Rb 1, Rc and Rd, respectively, based on comparison of retention time with those of standards by HPLC, and analysis on their API-MS/MS data. Ginsenoside Ro and chikuseksusaponin IVa are the major components of Kou zi qi. Conclusion: This plant had a close relationship to P. stipuleanatus, P. zinginensis and P. japonicus var major; a relatively remote relationship to P. ginseng and P. quinquefolius, in a view of chemotaxanology. Ginsenoside Ro and chikuseksusaponin IVa might be the anti-inflammatory constituents of Kou zi qi.

KW - Ginsenosides

KW - Kou zi qi

KW - Panax

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M3 - 学術論文

C2 - 15338885

AN - SCOPUS:4544252290

SN - 0513-4870

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JO - Yaoxue Xuebao

JF - Yaoxue Xuebao

IS - 5

ER -

Research of ginsenosides in Kou zi qi using HPLC-MS-MS

Abstract

Keywords

ASJC Scopus subject areas

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