Relationship between the water structure in the vicinity of carboxybetaine polymers and their biocompatibility

Susumu Tada*, Kazuya Mizukami, Makoto Gemmei-Ide, Hiromi Kitano, Masaru Tanaka

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review

Abstract

Structure of water in the vicinity of carboxybetaine(CMB), n-buthyl methacrylate(BMA) polymers and their copolymers with various compositions was investigated by using vibrational spectroscopies. Raman spectroscopy has revealed that, in contrast with ordinary polyelectrolytes, the zwitterionic polymers, PCMB and water-soluble P(BMA/CMB), did not affect the hydrogen-bonded network structure of water in their aqueous solutions. ATR-IR spectra of water sorbed into the P(BMA/CMB) films was similar to that of free water, but that in PBMA film was not. On the other hand, number of platelets adhered to the P(BMA/CMB) films was much smaller than that of PBMA film. These results suggest that the water structure is very important factor to generate biocompatibility of polymers.

Original languageEnglish
Pages1132
Number of pages1
StatePublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005/05/252005/05/27

Conference

Conference54th SPSJ Annual Meeting 2005
Country/TerritoryJapan
CityYokohama
Period2005/05/252005/05/27

Keywords

  • Biocompatibility
  • Carboxybetain polymer
  • Water structure

ASJC Scopus subject areas

  • General Engineering

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