Recurrent drug-induced liver injury caused by the incidental readministration of a kampo formula containing scutellariae radix

Yutaka Shimada; Makoto Fujimoto; Tatsuya Nogami; Hidetoshi Watari; Hideyuki Kitahara; Hiroki Misawa; Yoshiyuki Kimbara; Kei Ichiro Kita

doi:10.2169/internalmedicine.0275-17

Recurrent drug-induced liver injury caused by the incidental readministration of a kampo formula containing scutellariae radix

Yutaka Shimada^*, Makoto Fujimoto, Tatsuya Nogami, Hidetoshi Watari, Hideyuki Kitahara, Hiroki Misawa, Yoshiyuki Kimbara, Kei Ichiro Kita

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.

Original language	English
Pages (from-to)	1733-1740
Number of pages	8
Journal	Internal Medicine
Volume	57
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.0275-17
State	Published - 2018

Keywords

Adverse drug event
Drug-induced liver injury
Kampo medicine
Saikokeishikankyoto
Scutellariae radix
Shosaikoto

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.0275-17

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title = "Recurrent drug-induced liver injury caused by the incidental readministration of a kampo formula containing scutellariae radix",

abstract = "A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.",

keywords = "Adverse drug event, Drug-induced liver injury, Kampo medicine, Saikokeishikankyoto, Scutellariae radix, Shosaikoto",

author = "Yutaka Shimada and Makoto Fujimoto and Tatsuya Nogami and Hidetoshi Watari and Hideyuki Kitahara and Hiroki Misawa and Yoshiyuki Kimbara and Kita, {Kei Ichiro}",

note = "Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Internal Medicine.",

year = "2018",

doi = "10.2169/internalmedicine.0275-17",

language = "英語",

volume = "57",

pages = "1733--1740",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

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T1 - Recurrent drug-induced liver injury caused by the incidental readministration of a kampo formula containing scutellariae radix

AU - Shimada, Yutaka

AU - Fujimoto, Makoto

AU - Nogami, Tatsuya

AU - Watari, Hidetoshi

AU - Kitahara, Hideyuki

AU - Misawa, Hiroki

AU - Kimbara, Yoshiyuki

AU - Kita, Kei Ichiro

PY - 2018

Y1 - 2018

N2 - A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.

AB - A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.

KW - Adverse drug event

KW - Drug-induced liver injury

KW - Kampo medicine

KW - Saikokeishikankyoto

KW - Scutellariae radix

KW - Shosaikoto

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U2 - 10.2169/internalmedicine.0275-17

DO - 10.2169/internalmedicine.0275-17

M3 - 学術論文

C2 - 29434136

AN - SCOPUS:85048611927

SN - 0918-2918

VL - 57

SP - 1733

EP - 1740

JO - Internal Medicine

JF - Internal Medicine

IS - 12

ER -

Recurrent drug-induced liver injury caused by the incidental readministration of a kampo formula containing scutellariae radix

Abstract

Keywords

ASJC Scopus subject areas

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