Reciprocal IL-1β gene expression in medial and lateral hypothalamic areas in SART-stressed mice

Hiromi Tagoh; Hisao Nishijo; Teruko Uwano; Hiroyuki Kishi; Taketoshi Ono; Atsushi Muraguchi

doi:10.1016/0304-3940(94)11157-E

Reciprocal IL-1β gene expression in medial and lateral hypothalamic areas in SART-stressed mice

Hiromi Tagoh, Hisao Nishijo, Teruko Uwano, Hiroyuki Kishi, Taketoshi Ono, Atsushi Muraguchi^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Specific alteration of rhythm of temperature (SART) stress has been found to induce thymic atrophy via activation of the hypothalamus-pituitary-adrenal (HPA) axis. We demonstrate here that SART stress induces increment of IL-1β mRNA levels in the medial hypothalamic area (MHA) and decrement of IL-1β mRNA levels in the lateral hypothalamic area (LHA). The altered levels of IL-1β expression in these: loci return to those of non-stressed mice upon cessation of the stress. These data imply that the reciprocal wave of SART stress-induced IL- 1β gene expression in MHA and LHA may contribute to activation of the HPA axis and the resulting immunological dysfunction.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Neuroscience Letters
Volume	184
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)11157-E
State	Published - 1995/01/16

Keywords

Hypothalamus-pituitary-adrenal (HPA) axis
IL-1β mRNA
Lateral hypothalamic area (LHA)
Medial hypothalamic area (MHA)
Specific alteration of rhythm of temperature (SART) stress
Thymic atrophy

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)11157-E

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@article{d8c40e3444d841aba5a1604f8f66fa68,

title = "Reciprocal IL-1β gene expression in medial and lateral hypothalamic areas in SART-stressed mice",

abstract = "Specific alteration of rhythm of temperature (SART) stress has been found to induce thymic atrophy via activation of the hypothalamus-pituitary-adrenal (HPA) axis. We demonstrate here that SART stress induces increment of IL-1β mRNA levels in the medial hypothalamic area (MHA) and decrement of IL-1β mRNA levels in the lateral hypothalamic area (LHA). The altered levels of IL-1β expression in these: loci return to those of non-stressed mice upon cessation of the stress. These data imply that the reciprocal wave of SART stress-induced IL- 1β gene expression in MHA and LHA may contribute to activation of the HPA axis and the resulting immunological dysfunction.",

keywords = "Hypothalamus-pituitary-adrenal (HPA) axis, IL-1β mRNA, Lateral hypothalamic area (LHA), Medial hypothalamic area (MHA), Specific alteration of rhythm of temperature (SART) stress, Thymic atrophy",

author = "Hiromi Tagoh and Hisao Nishijo and Teruko Uwano and Hiroyuki Kishi and Taketoshi Ono and Atsushi Muraguchi",

note = "Funding Information: We thank Dr. A. Simpson, Showa University, for help in preparing this manuscript and Ms. Inoue for typing. This work was supported partly by the Japanese Ministry of Education, Science and Culture.",

year = "1995",

month = jan,

day = "16",

doi = "10.1016/0304-3940(94)11157-E",

language = "英語",

volume = "184",

pages = "17--20",

journal = "Neuroscience Letters",

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T1 - Reciprocal IL-1β gene expression in medial and lateral hypothalamic areas in SART-stressed mice

AU - Tagoh, Hiromi

AU - Nishijo, Hisao

AU - Uwano, Teruko

AU - Kishi, Hiroyuki

AU - Ono, Taketoshi

AU - Muraguchi, Atsushi

N1 - Funding Information: We thank Dr. A. Simpson, Showa University, for help in preparing this manuscript and Ms. Inoue for typing. This work was supported partly by the Japanese Ministry of Education, Science and Culture.

PY - 1995/1/16

Y1 - 1995/1/16

N2 - Specific alteration of rhythm of temperature (SART) stress has been found to induce thymic atrophy via activation of the hypothalamus-pituitary-adrenal (HPA) axis. We demonstrate here that SART stress induces increment of IL-1β mRNA levels in the medial hypothalamic area (MHA) and decrement of IL-1β mRNA levels in the lateral hypothalamic area (LHA). The altered levels of IL-1β expression in these: loci return to those of non-stressed mice upon cessation of the stress. These data imply that the reciprocal wave of SART stress-induced IL- 1β gene expression in MHA and LHA may contribute to activation of the HPA axis and the resulting immunological dysfunction.

AB - Specific alteration of rhythm of temperature (SART) stress has been found to induce thymic atrophy via activation of the hypothalamus-pituitary-adrenal (HPA) axis. We demonstrate here that SART stress induces increment of IL-1β mRNA levels in the medial hypothalamic area (MHA) and decrement of IL-1β mRNA levels in the lateral hypothalamic area (LHA). The altered levels of IL-1β expression in these: loci return to those of non-stressed mice upon cessation of the stress. These data imply that the reciprocal wave of SART stress-induced IL- 1β gene expression in MHA and LHA may contribute to activation of the HPA axis and the resulting immunological dysfunction.

KW - Hypothalamus-pituitary-adrenal (HPA) axis

KW - IL-1β mRNA

KW - Lateral hypothalamic area (LHA)

KW - Medial hypothalamic area (MHA)

KW - Specific alteration of rhythm of temperature (SART) stress

KW - Thymic atrophy

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U2 - 10.1016/0304-3940(94)11157-E

DO - 10.1016/0304-3940(94)11157-E

M3 - 学術論文

C2 - 7739797

AN - SCOPUS:0028985352

SN - 0304-3940

VL - 184

SP - 17

EP - 20

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Reciprocal IL-1β gene expression in medial and lateral hypothalamic areas in SART-stressed mice

Abstract

Keywords

ASJC Scopus subject areas

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