Recent Advances in the Synthesis of Benzothiazole and its Derivatives

Tanzeela Qadir, Andleeb Amin, Alka Salhotra, Praveen Kumar Sharma*, Ishtiaq Jeelani, Hitoshi Abe

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.

Original languageEnglish
Pages (from-to)189-214
Number of pages26
JournalCurrent Organic Chemistry
Volume26
Issue number2
DOIs
StatePublished - 2022/01

Keywords

  • 2-aminothiophenol
  • Aldehydes
  • Benzothiazoles
  • Condensation
  • Cyclization
  • Green chemistry
  • Nitriles
  • Thioamides

ASJC Scopus subject areas

  • Organic Chemistry

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