TY - JOUR
T1 - Radical scavenging by N-aminoazaaromatics
AU - Itoh, Takashi
AU - Miyazaki, Michiko
AU - Maeta, Hiromi
AU - Matsuya, Yûji
AU - Nagata, Kazuhiro
AU - Ohsawa, Akio
N1 - Funding Information:
The authors are grateful to Professor Masaaki Hirobe (the President of University of Shizuoka) for helpful discussions and many insightful comments. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 2000/8
Y1 - 2000/8
N2 - N-Aminoazaaromatics were found to react with nitric oxide in the presence of oxygen to afford deaminated products in high yields. The reaction proceeded almost instantaneously in various solvents including water, and one to two equivalent of NO was consumed depending upon the amount of oxygen coexisted, and 1 equivalent of N2O was released in the reaction. In addition, N-aminoazoles were deaminated by potassium superoxide to give parent azoles in good yields. Two equivalents of superoxide was consumed, and about half equivalents of both nitrite and nitrate ion were released. The results demonstrated that N-aminoazoles have ability to protect the biological system against the oxidation promoted by radicals such as nitrogen oxides and superoxide. Copyright (C) 2000 Elsevier Science Ltd.
AB - N-Aminoazaaromatics were found to react with nitric oxide in the presence of oxygen to afford deaminated products in high yields. The reaction proceeded almost instantaneously in various solvents including water, and one to two equivalent of NO was consumed depending upon the amount of oxygen coexisted, and 1 equivalent of N2O was released in the reaction. In addition, N-aminoazoles were deaminated by potassium superoxide to give parent azoles in good yields. Two equivalents of superoxide was consumed, and about half equivalents of both nitrite and nitrate ion were released. The results demonstrated that N-aminoazoles have ability to protect the biological system against the oxidation promoted by radicals such as nitrogen oxides and superoxide. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0033859140&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(00)00118-8
DO - 10.1016/S0968-0896(00)00118-8
M3 - 学術論文
C2 - 11003143
AN - SCOPUS:0033859140
SN - 0968-0896
VL - 8
SP - 1983
EP - 1989
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 8
ER -