TY - JOUR
T1 - Quantitative Susceptibility Mapping at 3 T and 1.5 T
T2 - Evaluation of Consistency and Reproducibility
AU - Hinoda, Takuya
AU - Fushimi, Yasutaka
AU - Okada, Tomohisa
AU - Fujimoto, Koji
AU - Liu, Chunlei
AU - Yamamoto, Akira
AU - Okada, Tsutomu
AU - Kido, Aki
AU - Togashi, Kaori
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015/8/21
Y1 - 2015/8/21
N2 - Objectives The aim of this study was to assess the consistency and reproducibility of quantitative susceptibility mapping (QSM) at 3-T and 1.5-T magnetic resonance (MR) scanners. Materials and Methods This study was approved by institutional ethics committee, and written informed consent was obtained. Twenty-two healthy volunteers underwent 2 examinations on different days. Each examination consisted of MR imaging on both 3-T and 1.5-T MR scanners. The data from both scanners and examination days were obtained, and QSM was calculated with STI Suite using 2 different algorithms-harmonic phase removal using laplacian operator (HARPERELLA) and a sophisticated harmonic artifact reduction for phase data (SHARP) method with a variable radius of the spherical kernel at the brain boundary (V-SHARP). We evaluated consistency of QSM between 3 T and 1.5 T and the reproducibility between the first and second examinations using 2-phase processing methods (HARPERELLA and V-SHARP). Results Susceptibility values of regions of interests at 3 T were highly correlated with those at 1.5 T with good agreement (HARPERELLA, R2 = 0.838; V-SHARP, R2 = 0.898) (average difference, ±1.96 SD; HARPERELLA,-0.012 ± 0.046; V-SHARP,-0.002 ± 0.034). Reproducibility analysis demonstrated excellent correlation between the first and second examination at both 3 T and 1.5 T for both algorithms (HARPERELLA at 3 T, R2 = 0.921; 1.5 T, R2 = 0.891; V-SHARP at 3 T, R2 = 0.937; 1.5 T, R2 = 0.926). Bland-Altman analysis showed excellent reproducibility for HARPERELLA (3 T,-0.003 ± 0.032; 1.5 T,-0.003 ± 0.038) and V-SHARP (3 T,-0.003 ± 0.027; 1.5 T,-0.003 ± 0.029). Susceptibility values of these 2 algorithms were highly correlated with good agreement (3T, R2 = 0.961; 1.5 T, R2 = 0.931) (3 T, 0.009 ± 0.023; 1.5 T,-0.003 ± 0.049). Conclusions Quantitative susceptibility mapping with HARPERELLA and V-SHARP demonstrated good reproducibility at 3 T and 1.5 T, and QSM with V-SHARP demonstrated good consistency at 3 T and 1.5 T.
AB - Objectives The aim of this study was to assess the consistency and reproducibility of quantitative susceptibility mapping (QSM) at 3-T and 1.5-T magnetic resonance (MR) scanners. Materials and Methods This study was approved by institutional ethics committee, and written informed consent was obtained. Twenty-two healthy volunteers underwent 2 examinations on different days. Each examination consisted of MR imaging on both 3-T and 1.5-T MR scanners. The data from both scanners and examination days were obtained, and QSM was calculated with STI Suite using 2 different algorithms-harmonic phase removal using laplacian operator (HARPERELLA) and a sophisticated harmonic artifact reduction for phase data (SHARP) method with a variable radius of the spherical kernel at the brain boundary (V-SHARP). We evaluated consistency of QSM between 3 T and 1.5 T and the reproducibility between the first and second examinations using 2-phase processing methods (HARPERELLA and V-SHARP). Results Susceptibility values of regions of interests at 3 T were highly correlated with those at 1.5 T with good agreement (HARPERELLA, R2 = 0.838; V-SHARP, R2 = 0.898) (average difference, ±1.96 SD; HARPERELLA,-0.012 ± 0.046; V-SHARP,-0.002 ± 0.034). Reproducibility analysis demonstrated excellent correlation between the first and second examination at both 3 T and 1.5 T for both algorithms (HARPERELLA at 3 T, R2 = 0.921; 1.5 T, R2 = 0.891; V-SHARP at 3 T, R2 = 0.937; 1.5 T, R2 = 0.926). Bland-Altman analysis showed excellent reproducibility for HARPERELLA (3 T,-0.003 ± 0.032; 1.5 T,-0.003 ± 0.038) and V-SHARP (3 T,-0.003 ± 0.027; 1.5 T,-0.003 ± 0.029). Susceptibility values of these 2 algorithms were highly correlated with good agreement (3T, R2 = 0.961; 1.5 T, R2 = 0.931) (3 T, 0.009 ± 0.023; 1.5 T,-0.003 ± 0.049). Conclusions Quantitative susceptibility mapping with HARPERELLA and V-SHARP demonstrated good reproducibility at 3 T and 1.5 T, and QSM with V-SHARP demonstrated good consistency at 3 T and 1.5 T.
KW - harmonic phase removal using laplacian operator
KW - magnetic resonance imaging
KW - quantitative susceptibility mapping
KW - variable radius of the spherical kernel at the brain boundary
UR - http://www.scopus.com/inward/record.url?scp=84937557525&partnerID=8YFLogxK
U2 - 10.1097/RLI.0000000000000159
DO - 10.1097/RLI.0000000000000159
M3 - 学術論文
C2 - 25900085
AN - SCOPUS:84937557525
SN - 0020-9996
VL - 50
SP - 522
EP - 530
JO - Investigative Radiology
JF - Investigative Radiology
IS - 8
ER -