Proteomic approach to apoptotic thymus maturation

Takao Kawakami; Takuya Nagata; Atsushi Muraguchi; Toshihide Nishimura

doi:10.1016/S1570-0232(02)00174-5

Proteomic approach to apoptotic thymus maturation

Takao Kawakami, Takuya Nagata, Atsushi Muraguchi, Toshihide Nishimura^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death.

Original language	English
Pages (from-to)	223-229
Number of pages	7
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	787
Issue number	1
DOIs	https://doi.org/10.1016/S1570-0232(02)00174-5
State	Published - 2003/04/05

Keywords

Apoptotic thymus maturation
Proteomics

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Clinical Biochemistry
Cell Biology

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10.1016/S1570-0232(02)00174-5

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title = "Proteomic approach to apoptotic thymus maturation",

abstract = "Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death.",

keywords = "Apoptotic thymus maturation, Proteomics",

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AU - Kawakami, Takao

AU - Nagata, Takuya

AU - Muraguchi, Atsushi

AU - Nishimura, Toshihide

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Y1 - 2003/4/5

N2 - Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death.

AB - Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death.

KW - Apoptotic thymus maturation

KW - Proteomics

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AN - SCOPUS:0037420399

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JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

IS - 1

ER -

Proteomic approach to apoptotic thymus maturation

Abstract

Keywords

ASJC Scopus subject areas

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