Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery

Eri N. Arai; Satoshi Yoneda; Noriko Yoneda; Mika Ito; Sayaka Tsuda; Arihiro Shiozaki; Tomoyoshi Nohira; Hironobu Hyodo; Kazumasa Kumazawa; Tomo Suzuki; Sumito Nagasaki; Shintaro Makino; Shigeru Saito

doi:10.1111/jog.15166

Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery

Eri N. Arai, Satoshi Yoneda, Noriko Yoneda, Mika Ito, Sayaka Tsuda, Arihiro Shiozaki, Tomoyoshi Nohira, Hironobu Hyodo, Kazumasa Kumazawa, Tomo Suzuki, Sumito Nagasaki, Shintaro Makino, Shigeru Saito^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Aim: A large cohort study of Japanese women reported that the rate of recurrent spontaneous preterm delivery (sPTD) in the next pregnancy was 22.3%; therefore, it is important to prevent recurrent sPTD. The present study investigated the rate of recurrent sPTD in pregnant women treated with probiotics. Methods: This was a retrospective study. Fifty-one pregnant women with a history of sPTD and who had been taking probiotics before 14 weeks of gestation were selected. The rate of sPTD in the next pregnancy among 255 pregnant women with a history of sPTD who had not taken probiotics was compared with that in the probiotics group. Results: The rate of recurrent sPTD was 9.8% (5/51), which was lower than previously reported values. Furthermore, the rate of recurrent sPTD was significantly lower in the probiotics group (9.8%) than in the nonprobiotics group (31.0% [79/255]; p = 0.002). Conclusions: Probiotics may reduce the rate of recurrent sPTD.

Original language	English
Pages (from-to)	688-693
Number of pages	6
Journal	Journal of Obstetrics and Gynaecology Research
Volume	48
Issue number	3
DOIs	https://doi.org/10.1111/jog.15166
State	Published - 2022/03

Keywords

Clostridium
multicenter study
preterm delivery
probiotics
recurrent spontaneous preterm delivery

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1111/jog.15166

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Arai, E. N., Yoneda, S., Yoneda, N., Ito, M., Tsuda, S., Shiozaki, A., Nohira, T., Hyodo, H., Kumazawa, K., Suzuki, T., Nagasaki, S., Makino, S., & Saito, S. (2022). Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery. Journal of Obstetrics and Gynaecology Research, 48(3), 688-693. https://doi.org/10.1111/jog.15166

@article{93ba23ee7db641c8a722ffd309f360f1,

title = "Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery",

abstract = "Aim: A large cohort study of Japanese women reported that the rate of recurrent spontaneous preterm delivery (sPTD) in the next pregnancy was 22.3%; therefore, it is important to prevent recurrent sPTD. The present study investigated the rate of recurrent sPTD in pregnant women treated with probiotics. Methods: This was a retrospective study. Fifty-one pregnant women with a history of sPTD and who had been taking probiotics before 14 weeks of gestation were selected. The rate of sPTD in the next pregnancy among 255 pregnant women with a history of sPTD who had not taken probiotics was compared with that in the probiotics group. Results: The rate of recurrent sPTD was 9.8% (5/51), which was lower than previously reported values. Furthermore, the rate of recurrent sPTD was significantly lower in the probiotics group (9.8%) than in the nonprobiotics group (31.0% [79/255]; p = 0.002). Conclusions: Probiotics may reduce the rate of recurrent sPTD.",

keywords = "Clostridium, multicenter study, preterm delivery, probiotics, recurrent spontaneous preterm delivery",

author = "Arai, {Eri N.} and Satoshi Yoneda and Noriko Yoneda and Mika Ito and Sayaka Tsuda and Arihiro Shiozaki and Tomoyoshi Nohira and Hironobu Hyodo and Kazumasa Kumazawa and Tomo Suzuki and Sumito Nagasaki and Shintaro Makino and Shigeru Saito",

note = "Publisher Copyright: {\textcopyright} 2022 Japan Society of Obstetrics and Gynecology.",

year = "2022",

month = mar,

doi = "10.1111/jog.15166",

language = "英語",

volume = "48",

pages = "688--693",

journal = "Journal of Obstetrics and Gynaecology Research",

issn = "1341-8076",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

Arai, EN, Yoneda, S , Yoneda, N, Ito, M, Tsuda, S, Shiozaki, A, Nohira, T, Hyodo, H, Kumazawa, K, Suzuki, T, Nagasaki, S, Makino, S & Saito, S 2022, 'Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery', Journal of Obstetrics and Gynaecology Research, vol. 48, no. 3, pp. 688-693. https://doi.org/10.1111/jog.15166

TY - JOUR

T1 - Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery

AU - Arai, Eri N.

AU - Yoneda, Satoshi

AU - Yoneda, Noriko

AU - Ito, Mika

AU - Tsuda, Sayaka

AU - Shiozaki, Arihiro

AU - Nohira, Tomoyoshi

AU - Hyodo, Hironobu

AU - Kumazawa, Kazumasa

AU - Suzuki, Tomo

AU - Nagasaki, Sumito

AU - Makino, Shintaro

AU - Saito, Shigeru

PY - 2022/3

Y1 - 2022/3

N2 - Aim: A large cohort study of Japanese women reported that the rate of recurrent spontaneous preterm delivery (sPTD) in the next pregnancy was 22.3%; therefore, it is important to prevent recurrent sPTD. The present study investigated the rate of recurrent sPTD in pregnant women treated with probiotics. Methods: This was a retrospective study. Fifty-one pregnant women with a history of sPTD and who had been taking probiotics before 14 weeks of gestation were selected. The rate of sPTD in the next pregnancy among 255 pregnant women with a history of sPTD who had not taken probiotics was compared with that in the probiotics group. Results: The rate of recurrent sPTD was 9.8% (5/51), which was lower than previously reported values. Furthermore, the rate of recurrent sPTD was significantly lower in the probiotics group (9.8%) than in the nonprobiotics group (31.0% [79/255]; p = 0.002). Conclusions: Probiotics may reduce the rate of recurrent sPTD.

AB - Aim: A large cohort study of Japanese women reported that the rate of recurrent spontaneous preterm delivery (sPTD) in the next pregnancy was 22.3%; therefore, it is important to prevent recurrent sPTD. The present study investigated the rate of recurrent sPTD in pregnant women treated with probiotics. Methods: This was a retrospective study. Fifty-one pregnant women with a history of sPTD and who had been taking probiotics before 14 weeks of gestation were selected. The rate of sPTD in the next pregnancy among 255 pregnant women with a history of sPTD who had not taken probiotics was compared with that in the probiotics group. Results: The rate of recurrent sPTD was 9.8% (5/51), which was lower than previously reported values. Furthermore, the rate of recurrent sPTD was significantly lower in the probiotics group (9.8%) than in the nonprobiotics group (31.0% [79/255]; p = 0.002). Conclusions: Probiotics may reduce the rate of recurrent sPTD.

KW - Clostridium

KW - multicenter study

KW - preterm delivery

KW - probiotics

KW - recurrent spontaneous preterm delivery

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U2 - 10.1111/jog.15166

DO - 10.1111/jog.15166

M3 - 学術論文

C2 - 35081670

AN - SCOPUS:85123600554

SN - 1341-8076

VL - 48

SP - 688

EP - 693

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

IS - 3

ER -

Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery

Abstract

Keywords

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