Prenylated Dihydrochalcones from Artocarpus altilis as Antiausterity Agents

Mai Thanh Thi Nguyen*, Nhan Trung Nguyen, Suresh Awale

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. A novel antiausterity strategy in anticancer drug discovery led to the discovery of agents that preferentially inhibit the survival of cancer cells under low nutrient conditions. Artocarpus altilis (Family: Moraceae) is commonly referred to as breadfruit, traditionally for the treatment of many diseases. Many prenylated flavonoid and prenylated chalocones together with their cancer cell cytotoxicity were reported from this plant. This chapter briefly summarizes the constituents, biosynthesis, cytotoxicity, and antiausterity activity on PANC-1 human pancreatic cancer cell line of A. altilis.

Original languageEnglish
Title of host publicationMechanism of the Anticancer Effect of Phytochemicals, 2015
EditorsFuyuhiko Tamanoi, S. Zahra Bathaie
PublisherAcademic Press
Pages95-110
Number of pages16
ISBN (Print)9780128038765
DOIs
StatePublished - 2015

Publication series

NameEnzymes
Volume37
ISSN (Print)1874-6047

Keywords

  • Antiausterity activity
  • Artocarpus altilis
  • Pancreatic cancer
  • P,renylated dihydrochalcone

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biochemistry
  • Molecular Biology

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