Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging

Koichi Okuda; Naoto Watanabe; Mitsumasa Hashimoto; Mariko Doai; Yasuyuki Kawai; Tomoko Takahashi; Tomohiro Arikawa; Kazumasa Ooiso; Yumi Sunatani; Kuniyoshi Iwabuchi; Koji Kajinami; Munetaka Matoba

doi:10.1016/j.apradiso.2019.108890

Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging

Koichi Okuda^*, Naoto Watanabe, Mitsumasa Hashimoto, Mariko Doai, Yasuyuki Kawai, Tomoko Takahashi, Tomohiro Arikawa, Kazumasa Ooiso, Yumi Sunatani, Kuniyoshi Iwabuchi, Koji Kajinami, Munetaka Matoba

^*Corresponding author for this work

Diagnostic and Therapeutic Radiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

DNA double-strand breaks (DSBs) of peripheral blood lymphocyte were prospectively assessed in 9 patients who were injected with ²⁰¹Tl-chloride and ¹²³I-beta-methyl-p-iodophenyl-pentadecanoic acid in dual-isotope imaging. Phosphorylated H2AX (γH2AX) was used as a biomarker for detecting DSBs, and the mean number of γH2AX foci per cell was measured microscopically. Mean γH2AX foci before administration of radiopharmaceuticals and at 3, 6, and 24 h following administration were 0.22 ± 0.34, 0.10 ± 0.14, 0.59 ± 0.46, and 0.52 ± 0.40, respectively (p = n.s. for all combinations).

Original language	English
Article number	108890
Journal	Applied Radiation and Isotopes
Volume	154
DOIs	https://doi.org/10.1016/j.apradiso.2019.108890
State	Published - 2019/12

Keywords

I-123
Myocardial perfusion imaging
Radiation exposure
Single photon emission computed tomography
Tl-201

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2019.108890

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Okuda, K., Watanabe, N., Hashimoto, M., Doai, M., Kawai, Y., Takahashi, T., Arikawa, T., Ooiso, K., Sunatani, Y., Iwabuchi, K., Kajinami, K., & Matoba, M. (2019). Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging. Applied Radiation and Isotopes, 154, Article 108890. https://doi.org/10.1016/j.apradiso.2019.108890

@article{08fa688c7eb84ef1bf5d7deb8b39a294,

title = "Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging",

abstract = "DNA double-strand breaks (DSBs) of peripheral blood lymphocyte were prospectively assessed in 9 patients who were injected with 201Tl-chloride and 123I-beta-methyl-p-iodophenyl-pentadecanoic acid in dual-isotope imaging. Phosphorylated H2AX (γH2AX) was used as a biomarker for detecting DSBs, and the mean number of γH2AX foci per cell was measured microscopically. Mean γH2AX foci before administration of radiopharmaceuticals and at 3, 6, and 24 h following administration were 0.22 ± 0.34, 0.10 ± 0.14, 0.59 ± 0.46, and 0.52 ± 0.40, respectively (p = n.s. for all combinations).",

keywords = "I-123, Myocardial perfusion imaging, Radiation exposure, Single photon emission computed tomography, Tl-201",

author = "Koichi Okuda and Naoto Watanabe and Mitsumasa Hashimoto and Mariko Doai and Yasuyuki Kawai and Tomoko Takahashi and Tomohiro Arikawa and Kazumasa Ooiso and Yumi Sunatani and Kuniyoshi Iwabuchi and Koji Kajinami and Munetaka Matoba",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

doi = "10.1016/j.apradiso.2019.108890",

language = "英語",

volume = "154",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Ltd.",

}

Okuda, K, Watanabe, N, Hashimoto, M, Doai, M, Kawai, Y, Takahashi, T, Arikawa, T, Ooiso, K, Sunatani, Y, Iwabuchi, K, Kajinami, K & Matoba, M 2019, 'Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging', Applied Radiation and Isotopes, vol. 154, 108890. https://doi.org/10.1016/j.apradiso.2019.108890

TY - JOUR

T1 - Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging

AU - Okuda, Koichi

AU - Watanabe, Naoto

AU - Hashimoto, Mitsumasa

AU - Doai, Mariko

AU - Kawai, Yasuyuki

AU - Takahashi, Tomoko

AU - Arikawa, Tomohiro

AU - Ooiso, Kazumasa

AU - Sunatani, Yumi

AU - Iwabuchi, Kuniyoshi

AU - Kajinami, Koji

AU - Matoba, Munetaka

PY - 2019/12

Y1 - 2019/12

N2 - DNA double-strand breaks (DSBs) of peripheral blood lymphocyte were prospectively assessed in 9 patients who were injected with 201Tl-chloride and 123I-beta-methyl-p-iodophenyl-pentadecanoic acid in dual-isotope imaging. Phosphorylated H2AX (γH2AX) was used as a biomarker for detecting DSBs, and the mean number of γH2AX foci per cell was measured microscopically. Mean γH2AX foci before administration of radiopharmaceuticals and at 3, 6, and 24 h following administration were 0.22 ± 0.34, 0.10 ± 0.14, 0.59 ± 0.46, and 0.52 ± 0.40, respectively (p = n.s. for all combinations).

AB - DNA double-strand breaks (DSBs) of peripheral blood lymphocyte were prospectively assessed in 9 patients who were injected with 201Tl-chloride and 123I-beta-methyl-p-iodophenyl-pentadecanoic acid in dual-isotope imaging. Phosphorylated H2AX (γH2AX) was used as a biomarker for detecting DSBs, and the mean number of γH2AX foci per cell was measured microscopically. Mean γH2AX foci before administration of radiopharmaceuticals and at 3, 6, and 24 h following administration were 0.22 ± 0.34, 0.10 ± 0.14, 0.59 ± 0.46, and 0.52 ± 0.40, respectively (p = n.s. for all combinations).

KW - I-123

KW - Myocardial perfusion imaging

KW - Radiation exposure

KW - Single photon emission computed tomography

KW - Tl-201

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U2 - 10.1016/j.apradiso.2019.108890

DO - 10.1016/j.apradiso.2019.108890

M3 - 学術論文

C2 - 31525597

AN - SCOPUS:85072064677

SN - 0969-8043

VL - 154

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 108890

ER -

Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging

Abstract

Keywords

ASJC Scopus subject areas

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