Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

Lamjed Bouslama; Kyoko Hayashi; Jung Bum Lee; Abdelwahed Ghorbel; Toshimitsu Hayashi

doi:10.1007/s11418-010-0468-8

Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

Lamjed Bouslama, Kyoko Hayashi, Jung Bum Lee, Abdelwahed Ghorbel, Toshimitsu Hayashi^*

^*Corresponding author for this work

Plant Resource Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)]. Only ethanol extract from the cactus stem showed significant antiviral activity in vitro. Two chlorophyll derivatives, pheophorbide a and pyropheophorbide a, were isolated as active substances exhibiting potent virucidal effects on HSV-2 and IFV-A, but no activity against PV-1 was observed. These findings suggest that these active compounds might recognize specific glycoproteins of enveloped viruses, precluding their binding to host cell receptors and inhibiting viral infections.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	Natural Medicines
Volume	65
Issue number	1
DOIs	https://doi.org/10.1007/s11418-010-0468-8
State	Published - 2011/01

Keywords

Cactus
Enveloped virus
Pheophorbide a
Pyropheophorbide a
Virucidal effect

ASJC Scopus subject areas

Molecular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11418-010-0468-8

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title = "Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses",

abstract = "In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)]. Only ethanol extract from the cactus stem showed significant antiviral activity in vitro. Two chlorophyll derivatives, pheophorbide a and pyropheophorbide a, were isolated as active substances exhibiting potent virucidal effects on HSV-2 and IFV-A, but no activity against PV-1 was observed. These findings suggest that these active compounds might recognize specific glycoproteins of enveloped viruses, precluding their binding to host cell receptors and inhibiting viral infections.",

keywords = "Cactus, Enveloped virus, Pheophorbide a, Pyropheophorbide a, Virucidal effect",

author = "Lamjed Bouslama and Kyoko Hayashi and Lee, {Jung Bum} and Abdelwahed Ghorbel and Toshimitsu Hayashi",

note = "Funding Information: Acknowledgments This work was supported by JICA (Japanese International Cooperation Agency). The authors graciously thank JICA for their financial and logistical supports. The authors are grateful to Ines Karkour (Center of Biotechnology of Borj Cedria), Lassaad Chouba (National Institute of Marine Science and Technology, La Goulette) and Lamia Trabelsi (National Institute of Marine Science and Technology, Monastir) for their contribution in the lyophilization of plant materials.",

year = "2011",

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doi = "10.1007/s11418-010-0468-8",

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pages = "229--233",

journal = "Natural Medicines",

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AU - Bouslama, Lamjed

AU - Hayashi, Kyoko

AU - Lee, Jung Bum

AU - Ghorbel, Abdelwahed

AU - Hayashi, Toshimitsu

N1 - Funding Information: Acknowledgments This work was supported by JICA (Japanese International Cooperation Agency). The authors graciously thank JICA for their financial and logistical supports. The authors are grateful to Ines Karkour (Center of Biotechnology of Borj Cedria), Lassaad Chouba (National Institute of Marine Science and Technology, La Goulette) and Lamia Trabelsi (National Institute of Marine Science and Technology, Monastir) for their contribution in the lyophilization of plant materials.

PY - 2011/1

Y1 - 2011/1

N2 - In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)]. Only ethanol extract from the cactus stem showed significant antiviral activity in vitro. Two chlorophyll derivatives, pheophorbide a and pyropheophorbide a, were isolated as active substances exhibiting potent virucidal effects on HSV-2 and IFV-A, but no activity against PV-1 was observed. These findings suggest that these active compounds might recognize specific glycoproteins of enveloped viruses, precluding their binding to host cell receptors and inhibiting viral infections.

AB - In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)]. Only ethanol extract from the cactus stem showed significant antiviral activity in vitro. Two chlorophyll derivatives, pheophorbide a and pyropheophorbide a, were isolated as active substances exhibiting potent virucidal effects on HSV-2 and IFV-A, but no activity against PV-1 was observed. These findings suggest that these active compounds might recognize specific glycoproteins of enveloped viruses, precluding their binding to host cell receptors and inhibiting viral infections.

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KW - Enveloped virus

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KW - Pyropheophorbide a

KW - Virucidal effect

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AN - SCOPUS:78651381961

SN - 1340-3443

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ER -

Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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