TY - JOUR
T1 - Pleiotropic and retinoprotective functions of PACAP
AU - Shioda, Seiji
AU - Takenoya, Fumiko
AU - Wada, Nobuhiro
AU - Hirabayashi, Takahiro
AU - Seki, Tamotsu
AU - Nakamachi, Tomoya
N1 - Publisher Copyright:
© 2016, Japanese Association of Anatomists.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues of the eye, including the retina, cornea and lacrimal gland, and PACAP is known to exert pleiotropic effects throughout the central nervous system. This review provides an overview of current knowledge regarding the cell protective effects, mechanisms of action and therapeutic potential of PACAP in response to several types of eye injury.
AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues of the eye, including the retina, cornea and lacrimal gland, and PACAP is known to exert pleiotropic effects throughout the central nervous system. This review provides an overview of current knowledge regarding the cell protective effects, mechanisms of action and therapeutic potential of PACAP in response to several types of eye injury.
KW - Dry eye
KW - Neurotropic function
KW - PACAP
KW - Retinoprotection
UR - http://www.scopus.com/inward/record.url?scp=84975292522&partnerID=8YFLogxK
U2 - 10.1007/s12565-016-0351-0
DO - 10.1007/s12565-016-0351-0
M3 - 総説
C2 - 27324639
AN - SCOPUS:84975292522
SN - 1447-6959
VL - 91
SP - 313
EP - 324
JO - Anatomical Science International
JF - Anatomical Science International
IS - 4
ER -