Photochemical Synthesis of Antitumor Platinum Pyrimidine Greens; Possible Contribution of Singlet Oxygen

Yohmei Okuno; Takenori Tomohiro; Takayuki Inoue; Osamu Yonemitsu; Tarja Laitalainen

doi:10.1248/cpb.35.3074

Photochemical Synthesis of Antitumor Platinum Pyrimidine Greens; Possible Contribution of Singlet Oxygen

Yohmei Okuno, Takenori Tomohiro, Takayuki Inoue, Osamu Yonemitsu, Tarja Laitalainen

Biorecognition Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A method is given for the selective synthesis of antitumor platinum greens in a reaction of the hydrolysis products of cis-diiododiammineplatinum (II) and nucleosides via visible-light induced oxidation. A role of singlet oxygen in the green formation is indicated by the sensitized reactions with methylene blue and rose bengal and by experimental quenching of singlet oxygen with 1,4-diaza-bicyclooctane (DABCO).

Original language	English
Pages (from-to)	3074-3077
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	7
DOIs	https://doi.org/10.1248/cpb.35.3074
State	Published - 1987

Keywords

DABCO quenching
antitumor activity
photosensitized reaction
platinum pyrimidine green
singlet oxygen

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.35.3074

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title = "Photochemical Synthesis of Antitumor Platinum Pyrimidine Greens; Possible Contribution of Singlet Oxygen",

abstract = "A method is given for the selective synthesis of antitumor platinum greens in a reaction of the hydrolysis products of cis-diiododiammineplatinum (II) and nucleosides via visible-light induced oxidation. A role of singlet oxygen in the green formation is indicated by the sensitized reactions with methylene blue and rose bengal and by experimental quenching of singlet oxygen with 1,4-diaza-bicyclooctane (DABCO).",

keywords = "DABCO quenching, antitumor activity, photosensitized reaction, platinum pyrimidine green, singlet oxygen",

author = "Yohmei Okuno and Takenori Tomohiro and Takayuki Inoue and Osamu Yonemitsu and Tarja Laitalainen",

year = "1987",

doi = "10.1248/cpb.35.3074",

language = "英語",

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journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Photochemical Synthesis of Antitumor Platinum Pyrimidine Greens; Possible Contribution of Singlet Oxygen

AU - Okuno, Yohmei

AU - Tomohiro, Takenori

AU - Inoue, Takayuki

AU - Yonemitsu, Osamu

AU - Laitalainen, Tarja

PY - 1987

Y1 - 1987

N2 - A method is given for the selective synthesis of antitumor platinum greens in a reaction of the hydrolysis products of cis-diiododiammineplatinum (II) and nucleosides via visible-light induced oxidation. A role of singlet oxygen in the green formation is indicated by the sensitized reactions with methylene blue and rose bengal and by experimental quenching of singlet oxygen with 1,4-diaza-bicyclooctane (DABCO).

AB - A method is given for the selective synthesis of antitumor platinum greens in a reaction of the hydrolysis products of cis-diiododiammineplatinum (II) and nucleosides via visible-light induced oxidation. A role of singlet oxygen in the green formation is indicated by the sensitized reactions with methylene blue and rose bengal and by experimental quenching of singlet oxygen with 1,4-diaza-bicyclooctane (DABCO).

KW - DABCO quenching

KW - antitumor activity

KW - photosensitized reaction

KW - platinum pyrimidine green

KW - singlet oxygen

UR - http://www.scopus.com/inward/record.url?scp=0023238984&partnerID=8YFLogxK

U2 - 10.1248/cpb.35.3074

DO - 10.1248/cpb.35.3074

M3 - 学術論文

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AN - SCOPUS:0023238984

SN - 0009-2363

VL - 35

SP - 3074

EP - 3077

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Photochemical Synthesis of Antitumor Platinum Pyrimidine Greens; Possible Contribution of Singlet Oxygen

Abstract

Keywords

ASJC Scopus subject areas

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