Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Mai T.T. Nguyen, Hai X. Nguyen, Phu H. Dang, Tho H. Le, Truong N.V. Do, Ashraf M. Omar, Suresh Awale, Nhan T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC50 value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q–Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q–S and U–W exhibited potent cytotoxicity towards PANC-1 cell line with the PC50 values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC50 value of 0.8 μM under nutrient-deprived medium.

Original languageEnglish
Article number112646
JournalPhytochemistry
Volume183
DOIs
StatePublished - 2021/03

Keywords

  • Boesenbergia rotunda
  • Dimeric metabolites
  • PANC-1 cell line
  • Panduratins
  • Zingiberaceae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Fingerprint

Dive into the research topics of 'Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line'. Together they form a unique fingerprint.

Cite this