Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Mai T.T. Nguyen; Hai X. Nguyen; Phu H. Dang; Tho H. Le; Truong N.V. Do; Ashraf M. Omar; Suresh Awale; Nhan T. Nguyen

doi:10.1016/j.phytochem.2020.112646

Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Mai T.T. Nguyen, Hai X. Nguyen, Phu H. Dang, Tho H. Le, Truong N.V. Do, Ashraf M. Omar, Suresh Awale, Nhan T. Nguyen^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC₅₀ value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q–Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q–S and U–W exhibited potent cytotoxicity towards PANC-1 cell line with the PC₅₀ values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC₅₀ value of 0.8 μM under nutrient-deprived medium.

Original language	English
Article number	112646
Journal	Phytochemistry
Volume	183
DOIs	https://doi.org/10.1016/j.phytochem.2020.112646
State	Published - 2021/03

Keywords

Boesenbergia rotunda
Dimeric metabolites
PANC-1 cell line
Panduratins
Zingiberaceae

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

Access to Document

10.1016/j.phytochem.2020.112646

Cite this

@article{23baaffc16c345f3a809628a74ec1b92,

title = "Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line",

abstract = "A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC50 value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q–Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q–S and U–W exhibited potent cytotoxicity towards PANC-1 cell line with the PC50 values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC50 value of 0.8 μM under nutrient-deprived medium.",

keywords = "Boesenbergia rotunda, Dimeric metabolites, PANC-1 cell line, Panduratins, Zingiberaceae",

author = "Nguyen, {Mai T.T.} and Nguyen, {Hai X.} and Dang, {Phu H.} and Le, {Tho H.} and Do, {Truong N.V.} and Omar, {Ashraf M.} and Suresh Awale and Nguyen, {Nhan T.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2021",

month = mar,

doi = "10.1016/j.phytochem.2020.112646",

language = "英語",

volume = "183",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

AU - Nguyen, Mai T.T.

AU - Nguyen, Hai X.

AU - Dang, Phu H.

AU - Le, Tho H.

AU - Do, Truong N.V.

AU - Omar, Ashraf M.

AU - Awale, Suresh

AU - Nguyen, Nhan T.

PY - 2021/3

Y1 - 2021/3

N2 - A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC50 value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q–Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q–S and U–W exhibited potent cytotoxicity towards PANC-1 cell line with the PC50 values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC50 value of 0.8 μM under nutrient-deprived medium.

AB - A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC50 value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q–Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q–S and U–W exhibited potent cytotoxicity towards PANC-1 cell line with the PC50 values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC50 value of 0.8 μM under nutrient-deprived medium.

KW - Boesenbergia rotunda

KW - Dimeric metabolites

KW - PANC-1 cell line

KW - Panduratins

KW - Zingiberaceae

UR - http://www.scopus.com/inward/record.url?scp=85098852674&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2020.112646

DO - 10.1016/j.phytochem.2020.112646

M3 - 学術論文

C2 - 33421887

AN - SCOPUS:85098852674

SN - 0031-9422

VL - 183

JO - Phytochemistry

JF - Phytochemistry

M1 - 112646

ER -

Panduratins Q–Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this