Palladium(0)-catalyzed cyclization-carbonylation of 2,7-octadienyl acetate and homologues

Masahiko Terakado*, Kouya Murai, Masahiro Miyazawa, Keiji Yamamoto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The palladium(0)-catalyzed carbonylations, in acetic acid as a necessary solvent, of 2,7-octadienyl acetate and homologues via π-allylpalladium species were preceded by their intramolecular olefin insertion to form mixtures of cis/trans-2-vinylcyclopentylacetyl- and cis/trans-cyclohexylacetylpalladium intermediates, which undergo further the intramolecular (5-exo) Heck reaction to give bicyclo-[3.3.0] and [4.3.0] skeletons, respectively, except for one case affording trans-2-vinylcyclopentylacetic acid as a major product.

Original languageEnglish
Pages (from-to)5705-5718
Number of pages14
JournalTetrahedron
Volume50
Issue number19
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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