Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review

Tibor Wenger; Kazuhito Watanabe; Yui Sasaki; Keiko Kanazawa; Koichi Shimizu; Supaart Sirikantaramas; Yoshinari Shoyama; Futoshi Taura; Satoshi Morimoto; Yukihiro Shoyama

doi:10.3389/fphar.2021.713228

Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review

Tibor Wenger, Kazuhito Watanabe, Yui Sasaki, Keiko Kanazawa, Koichi Shimizu, Supaart Sirikantaramas, Yoshinari Shoyama, Futoshi Taura, Satoshi Morimoto, Yukihiro Shoyama^*

^*Corresponding author for this work

Medicinal Bioresources

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Cannabis sativa L. is an annual herb oldest cultivated plants as a source of fiber since about 5000 B.C. On the other hand, the cannabis flower and seed are listed in Shennong’s classic Materia Medica approximately 2000 years ago. The formulas prescribed with cannabis in Kampo medicine have been summarized. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the major neurological and psychiatric cannabinoids, and develop to drugs. It becomes evident that the therapeutic CBD and/or THC are the important candidate of anti-dementia drugs having different mechanism for Alzheimer’s patients. Two receptors and endocannabinoids are also discussed for underlying mechanism of action. In order to promote the breeding of cannabis plant containing higher concentration of target cannabinoid the biosynthetic enzymes were isolated, cloning and the tertiary structure of THCA synthase determined by x-ray analysis resulting in the possibility of molecular breeding for cannabinoids.

Original language	English
Article number	713228
Journal	Frontiers in Pharmacology
Volume	12
DOIs	https://doi.org/10.3389/fphar.2021.713228
State	Published - 2022/03/01

Keywords

CB1 and CB2 receptor
Cannabis sativa
anti-dementia
cannabinoid biosynthetic enzyme
kampo medicine

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review",

abstract = "Cannabis sativa L. is an annual herb oldest cultivated plants as a source of fiber since about 5000 B.C. On the other hand, the cannabis flower and seed are listed in Shennong{\textquoteright}s classic Materia Medica approximately 2000 years ago. The formulas prescribed with cannabis in Kampo medicine have been summarized. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the major neurological and psychiatric cannabinoids, and develop to drugs. It becomes evident that the therapeutic CBD and/or THC are the important candidate of anti-dementia drugs having different mechanism for Alzheimer{\textquoteright}s patients. Two receptors and endocannabinoids are also discussed for underlying mechanism of action. In order to promote the breeding of cannabis plant containing higher concentration of target cannabinoid the biosynthetic enzymes were isolated, cloning and the tertiary structure of THCA synthase determined by x-ray analysis resulting in the possibility of molecular breeding for cannabinoids.",

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year = "2022",

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doi = "10.3389/fphar.2021.713228",

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AU - Sasaki, Yui

AU - Kanazawa, Keiko

AU - Shimizu, Koichi

AU - Sirikantaramas, Supaart

AU - Shoyama, Yoshinari

AU - Taura, Futoshi

AU - Morimoto, Satoshi

AU - Shoyama, Yukihiro

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AB - Cannabis sativa L. is an annual herb oldest cultivated plants as a source of fiber since about 5000 B.C. On the other hand, the cannabis flower and seed are listed in Shennong’s classic Materia Medica approximately 2000 years ago. The formulas prescribed with cannabis in Kampo medicine have been summarized. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the major neurological and psychiatric cannabinoids, and develop to drugs. It becomes evident that the therapeutic CBD and/or THC are the important candidate of anti-dementia drugs having different mechanism for Alzheimer’s patients. Two receptors and endocannabinoids are also discussed for underlying mechanism of action. In order to promote the breeding of cannabis plant containing higher concentration of target cannabinoid the biosynthetic enzymes were isolated, cloning and the tertiary structure of THCA synthase determined by x-ray analysis resulting in the possibility of molecular breeding for cannabinoids.

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Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review

Abstract

Keywords

ASJC Scopus subject areas

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