Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease

Shino Fujimoto; Tomoyuki Sakai; Hiroshi Kawabata; Nozomu Kurose; Sohsuke Yamada; Mariko Doai; Munetaka Matoba; Haruka Iwao-Kawanami; Takafumi Kawanami; Shuichi Mizuta; Toshihiro Fukushima; Hiroki Mizumaki; Masaki Yamaguchi; Yasufumi Masaki

doi:10.2169/internalmedicine.2738-19

Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease

Shino Fujimoto, Tomoyuki Sakai, Hiroshi Kawabata^*, Nozomu Kurose, Sohsuke Yamada, Mariko Doai, Munetaka Matoba, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Hiroki Mizumaki, Masaki Yamaguchi, Yasufumi Masaki

^*Corresponding author for this work

Diagnostic and Therapeutic Radiology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis.

Original language	English
Pages (from-to)	2555-2560
Number of pages	6
Journal	Internal Medicine
Volume	58
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.2738-19
State	Published - 2019

Keywords

Castleman disease
Diagnosis
Interleukin 6
Osteosarcoma

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.2738-19

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Fujimoto, S., Sakai, T., Kawabata, H., Kurose, N., Yamada, S., Doai, M., Matoba, M., Iwao-Kawanami, H., Kawanami, T., Mizuta, S., Fukushima, T., Mizumaki, H., Yamaguchi, M., & Masaki, Y. (2019). Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease. Internal Medicine, 58(17), 2555-2560. https://doi.org/10.2169/internalmedicine.2738-19

@article{d3b8966000784cecabee1435db0ec833,

title = "Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease",

abstract = "A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis.",

keywords = "Castleman disease, Diagnosis, Interleukin 6, Osteosarcoma",

author = "Shino Fujimoto and Tomoyuki Sakai and Hiroshi Kawabata and Nozomu Kurose and Sohsuke Yamada and Mariko Doai and Munetaka Matoba and Haruka Iwao-Kawanami and Takafumi Kawanami and Shuichi Mizuta and Toshihiro Fukushima and Hiroki Mizumaki and Masaki Yamaguchi and Yasufumi Masaki",

year = "2019",

doi = "10.2169/internalmedicine.2738-19",

language = "英語",

volume = "58",

pages = "2555--2560",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "17",

}

Fujimoto, S, Sakai, T, Kawabata, H, Kurose, N, Yamada, S, Doai, M, Matoba, M, Iwao-Kawanami, H, Kawanami, T, Mizuta, S, Fukushima, T, Mizumaki, H, Yamaguchi, M & Masaki, Y 2019, 'Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease', Internal Medicine, vol. 58, no. 17, pp. 2555-2560. https://doi.org/10.2169/internalmedicine.2738-19

TY - JOUR

T1 - Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease

AU - Fujimoto, Shino

AU - Sakai, Tomoyuki

AU - Kawabata, Hiroshi

AU - Kurose, Nozomu

AU - Yamada, Sohsuke

AU - Doai, Mariko

AU - Matoba, Munetaka

AU - Iwao-Kawanami, Haruka

AU - Kawanami, Takafumi

AU - Mizuta, Shuichi

AU - Fukushima, Toshihiro

AU - Mizumaki, Hiroki

AU - Yamaguchi, Masaki

AU - Masaki, Yasufumi

PY - 2019

Y1 - 2019

N2 - A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis.

AB - A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis.

KW - Castleman disease

KW - Diagnosis

KW - Interleukin 6

KW - Osteosarcoma

UR - http://www.scopus.com/inward/record.url?scp=85071786014&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.2738-19

DO - 10.2169/internalmedicine.2738-19

M3 - 学術論文

C2 - 31178507

AN - SCOPUS:85071786014

SN - 0918-2918

VL - 58

SP - 2555

EP - 2560

JO - Internal Medicine

JF - Internal Medicine

IS - 17

ER -

Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease

Abstract

Keywords

ASJC Scopus subject areas

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