TY - JOUR
T1 - Obesity and cardiac autonomic nerve activity in healthy children
T2 - Results of the Toyama Birth Cohort Study
AU - Sekine, M.
AU - Izumi, I.
AU - Yamagami, T.
AU - Kagamimori, S.
N1 - Funding Information:
This study was supported by grants from the Ministry of Health and Welfare (H10-Child-020), and the Toyama Medical Association. Funding organizations were not involved in the design, conduct, interpretation, and analysis of the study, nor review or approval of the manuscript.
PY - 2001
Y1 - 2001
N2 - Objectives: To determine the relationship between obesity and cardiac autonomic nerve activity in healthy children. Methods: 16 healthy male children comprising of 9 nonobese and 7 obese subjects (body mass index > 19.1 kg/m2) aged 8-9 years were selected. Electrocardiograms were measured for 10 min. under controlled ventilation (0.25 Hz) in the supine position. Consecutive 256-second RR interval data were transformed by the Fast Fourier Transform method into power spectral data. Very low frequency (VLF; 0.003-0.04 Hz), low frequency (LF; 0.04-0.15 Hz), high frequency (HF; 0.15-0.40 Hz), and total power (TP; 0.003-0.40 Hz) were calculated and transformed into a natural logarithm (In). Normalized units (nu) were also calculated as follows: LFnu = LF / (TP - VLF) x 100. HFnu = HF / (TP - VLF) x 100. Low/high-frequency ratio (LHR) was calculated as LF divided by HF. Unpaired t test was performed to compare the 2 groups. Results: TP In and HFnu, reflecting cardiac parasympathetic nerve activity, in obese children were significantly lower than those in nonobese children. In contrast, LFnu and LHF, reflecting cardiac sympathetic nerve activity, in obese children were significantly higher than those in nonobese children. Conclusions: These findings suggest that obese children have higher sympathetic nerve activity and lower parasympathetic nerve activity than nonobese children.
AB - Objectives: To determine the relationship between obesity and cardiac autonomic nerve activity in healthy children. Methods: 16 healthy male children comprising of 9 nonobese and 7 obese subjects (body mass index > 19.1 kg/m2) aged 8-9 years were selected. Electrocardiograms were measured for 10 min. under controlled ventilation (0.25 Hz) in the supine position. Consecutive 256-second RR interval data were transformed by the Fast Fourier Transform method into power spectral data. Very low frequency (VLF; 0.003-0.04 Hz), low frequency (LF; 0.04-0.15 Hz), high frequency (HF; 0.15-0.40 Hz), and total power (TP; 0.003-0.40 Hz) were calculated and transformed into a natural logarithm (In). Normalized units (nu) were also calculated as follows: LFnu = LF / (TP - VLF) x 100. HFnu = HF / (TP - VLF) x 100. Low/high-frequency ratio (LHR) was calculated as LF divided by HF. Unpaired t test was performed to compare the 2 groups. Results: TP In and HFnu, reflecting cardiac parasympathetic nerve activity, in obese children were significantly lower than those in nonobese children. In contrast, LFnu and LHF, reflecting cardiac sympathetic nerve activity, in obese children were significantly higher than those in nonobese children. Conclusions: These findings suggest that obese children have higher sympathetic nerve activity and lower parasympathetic nerve activity than nonobese children.
KW - Autonomic nerve activity
KW - Children
KW - Heart rate variability
KW - Obesity
KW - The Toyama Birth Cohort Study
UR - http://www.scopus.com/inward/record.url?scp=0034767259&partnerID=8YFLogxK
U2 - 10.1265/ehpm.2001.149
DO - 10.1265/ehpm.2001.149
M3 - 学術論文
AN - SCOPUS:0034767259
SN - 1342-078X
VL - 6
SP - 149
EP - 153
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine
IS - 3
ER -
