TY - JOUR
T1 - No effect of a traditional Chinese medicine, Hochu-ekki-to, on antibody titer after influenza vaccination in man
T2 - A randomized, placebo-controlled, double-blind trial
AU - Hamazaki, K.
AU - Sawazaki, S.
AU - Itomura, M.
AU - Huan, M.
AU - Shibahara, N.
AU - Kawakita, T.
AU - Kobayashi, S.
AU - Hamazaki, T.
N1 - Funding Information:
This study was supported in part by the Polyene Project Corporation. We are grateful to Ms Hiroko Hamatani and Ms Shizuko Takebe for their technical assistant.
PY - 2007/1/10
Y1 - 2007/1/10
N2 - Background: It was shown that a traditional Chinese medicine, Hochu-ekki-to (HET), had adjuvant effects in influenza vaccination in an animal experiment. This, however, could not be assessed in a clinical study. Methods: Thirty-two healthy subjects were randomly assigned to two groups (control and HET groups) in a double-blind manner. HET subjects (n = 17) took 7.5 g of HET/day for two weeks; control subjects took the same amount of indistinguishable placebo. Then subjects were vaccinated against influenza (H1N1, H3N2 and B/Shandong). Hemagglutinin titers and natural killer (NK) activity were measured at weeks 0, 1, 2, 4, and 12. Results: Antiinfluenza titers against the three viruses were increased continuously for the first two weeks and leveled off. However, there were no significant differences in any titers between the two groups. NK activity peaked at week 2 without any inter-group differences. Conclusion: We could not find any adjuvant effects of HET in this experimental condition.
AB - Background: It was shown that a traditional Chinese medicine, Hochu-ekki-to (HET), had adjuvant effects in influenza vaccination in an animal experiment. This, however, could not be assessed in a clinical study. Methods: Thirty-two healthy subjects were randomly assigned to two groups (control and HET groups) in a double-blind manner. HET subjects (n = 17) took 7.5 g of HET/day for two weeks; control subjects took the same amount of indistinguishable placebo. Then subjects were vaccinated against influenza (H1N1, H3N2 and B/Shandong). Hemagglutinin titers and natural killer (NK) activity were measured at weeks 0, 1, 2, 4, and 12. Results: Antiinfluenza titers against the three viruses were increased continuously for the first two weeks and leveled off. However, there were no significant differences in any titers between the two groups. NK activity peaked at week 2 without any inter-group differences. Conclusion: We could not find any adjuvant effects of HET in this experimental condition.
KW - Adjuvant
KW - Hochu-ekki-to
KW - Influenza vaccination
KW - Randomized clinical trial
KW - Traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=33845602715&partnerID=8YFLogxK
U2 - 10.1016/j.phymed.2006.02.002
DO - 10.1016/j.phymed.2006.02.002
M3 - 学術論文
C2 - 16644196
AN - SCOPUS:33845602715
SN - 0944-7113
VL - 14
SP - 11
EP - 14
JO - Phytomedicine
JF - Phytomedicine
IS - 1
ER -
