Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil

Suresh Awale; Tsukasa Kawakami; Yasuhiro Tezuka; Jun Ya Ueda; Ken Tanaka; Shigetoshi Kadota

doi:10.1248/cpb.53.710

Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil

Suresh Awale, Tsukasa Kawakami, Yasuhiro Tezuka, Jun Ya Ueda, Ken Tanaka, Shigetoshi Kadota^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC ₅₀, 13.8-26.1 μg/ml) than a positive control N^G- monomethyl-L-arginine (L-NMMA; IC₅₀, 27.4 μg/ml).

Original language	English
Pages (from-to)	710-713
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	6
DOIs	https://doi.org/10.1248/cpb.53.710
State	Published - 2005/06

Keywords

Anti-inflammatory
Iridoid
Nitric oxide (NO) production inhibitory activity
Phenylethanoid glycoside
Tabebuia avellanedae

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.53.710

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title = "Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil",

abstract = "From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC 50, 13.8-26.1 μg/ml) than a positive control NG- monomethyl-L-arginine (L-NMMA; IC50, 27.4 μg/ml).",

keywords = "Anti-inflammatory, Iridoid, Nitric oxide (NO) production inhibitory activity, Phenylethanoid glycoside, Tabebuia avellanedae",

author = "Suresh Awale and Tsukasa Kawakami and Yasuhiro Tezuka and Ueda, {Jun Ya} and Ken Tanaka and Shigetoshi Kadota",

year = "2005",

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doi = "10.1248/cpb.53.710",

language = "英語",

volume = "53",

pages = "710--713",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

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T1 - Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil

AU - Awale, Suresh

AU - Kawakami, Tsukasa

AU - Tezuka, Yasuhiro

AU - Ueda, Jun Ya

AU - Tanaka, Ken

AU - Kadota, Shigetoshi

PY - 2005/6

Y1 - 2005/6

N2 - From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC 50, 13.8-26.1 μg/ml) than a positive control NG- monomethyl-L-arginine (L-NMMA; IC50, 27.4 μg/ml).

AB - From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC 50, 13.8-26.1 μg/ml) than a positive control NG- monomethyl-L-arginine (L-NMMA; IC50, 27.4 μg/ml).

KW - Anti-inflammatory

KW - Iridoid

KW - Nitric oxide (NO) production inhibitory activity

KW - Phenylethanoid glycoside

KW - Tabebuia avellanedae

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DO - 10.1248/cpb.53.710

M3 - 学術論文

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SN - 0009-2363

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JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 6

ER -

Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil

Abstract

Keywords

ASJC Scopus subject areas

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