New strategy for the total synthesis of macrosphelides A and B based on ring-closing metathesis

Yuji Matsuya, Takanori Kawaguchi, Hideo Nemoto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

(Matrix presented) A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products.

Original languageEnglish
Pages (from-to)2939-2941
Number of pages3
JournalOrganic Letters
Volume5
Issue number16
DOIs
StatePublished - 2003/08/07

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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