Abstract
(Matrix presented) A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products.
Original language | English |
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Pages (from-to) | 2939-2941 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 5 |
Issue number | 16 |
DOIs | |
State | Published - 2003/08/07 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry