Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility

Issei Tokimatsu; Tetsuya Matsumoto; Hiroki Tsukada; Yuji Fujikura; Makoto Miki; Yoshitomo Morinaga; Junko Sato; Tomotaro Wakamura; Hiroshi Kiyota; Kazuhiro Tateda; Hideji Yanagisawa; Takaaki Sasaki; Hideki Ikeda; Hiroshi Horikawa; Hiroshi Takahashi; Masafumi Seki; Yoshiaki Mori; Hiroaki Takeda; Daisuke Kurai; Naoki Hasegawa; Yoshifumi Uwamino; Makoto Kudo; Masaki Yamamoto; Yuko Nagano; Sakika Nomura; Takafumi Tetsuka; Miyuki Hosokai; Nobuki Aoki; Yoshihiro Yamamoto; Yoshitsugu Iinuma; Hiroshige Mikamo; Hiroyuki Suematsu; Takaya Maruyama; Atsushi Kawabata; Yoshiko Sugaki; Atsushi Nakamura; Yasunori Fujikawa; Tatsuya Fukumori; Akira Ukimura; Hiroshi Kakeya; Makoto Niki; Koichiro Yoshida; Yoshihiro Kobashi; Hirokazu Tokuyasu; Kazuhiro Yatera; Hiroaki Ikegami; Masaki Fujita; Takemasa Matsumoto; Katsunori Yanagihara; Junichi Matsuda; Kazufumi Hiramatsu; Takashi Shinzato

doi:10.1016/j.jiac.2023.04.008

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility

Issei Tokimatsu^*, Tetsuya Matsumoto, Hiroki Tsukada, Yuji Fujikura, Makoto Miki, Yoshitomo Morinaga, Junko Sato, Tomotaro Wakamura, Hiroshi Kiyota, Kazuhiro Tateda, Hideji Yanagisawa, Takaaki Sasaki, Hideki Ikeda, Hiroshi Horikawa, Hiroshi Takahashi, Masafumi Seki, Yoshiaki Mori, Hiroaki Takeda, Daisuke Kurai, Naoki HasegawaYoshifumi Uwamino, Makoto Kudo, Masaki Yamamoto, Yuko Nagano, Sakika Nomura, Takafumi Tetsuka, Miyuki Hosokai, Nobuki Aoki, Yoshihiro Yamamoto, Yoshitsugu Iinuma, Hiroshige Mikamo, Hiroyuki Suematsu, Takaya Maruyama, Atsushi Kawabata, Yoshiko Sugaki, Atsushi Nakamura, Yasunori Fujikawa, Tatsuya Fukumori, Akira Ukimura, Hiroshi Kakeya, Makoto Niki, Koichiro Yoshida, Yoshihiro Kobashi, Hirokazu Tokuyasu, Kazuhiro Yatera, Hiroaki Ikegami, Masaki Fujita, Takemasa Matsumoto, Katsunori Yanagihara, Junichi Matsuda, Kazufumi Hiramatsu, Takashi Shinzato

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The trends and prevalence of antimicrobial susceptibility of pathogens vary by country, region, and time. Long-term regular surveillance is required to investigate trends in the antimicrobial resistance of various isolated bacterial pathogens. We report the results of a nationwide surveillance on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology. The isolates were collected from clinical specimens obtained from adult patients who visited a collaborating medical facility between June 2019 and December 2020 and were diagnosed with respiratory tract infections by a physician. Antimicrobial susceptibility testing was performed in a centralized laboratory according to the methods recommended by the Clinical and Laboratory Standards Institute. Susceptibility testing was performed for 932 strains (201 Staphylococcus aureus, 158 Streptococcus pneumoniae, 6 S. pyogenes, 136 Haemophilus influenzae, 127 Moraxella catarrhalis, 141 Klebsiella pneumoniae, and 163 Pseudomonas aeruginosa) collected from 32 facilities in Japan. The proportions of methicillin-resistant S. aureus and penicillin-resistant S. pneumoniae were 35.3% and 0%, respectively. In H. influenzae, 16.2% and 16.9% were β-lactamase-producing ampicillin resistant and β-lactamase-negative ampicillin resistant, respectively. Extended-spectrum β-lactamase-producing K. pneumoniae accounted for 5.0% of all K. pneumoniae infections. Carbapenemase-producing K. pneumoniae and multi-drug-resistant P. aeruginosa with metallo-β-lactamase were not detected in this study. This surveillance will be a useful reference for treating respiratory infections in Japan and will provide evidence to enhance the appropriate use of antimicrobial agents.

Original language	English
Pages (from-to)	731-743
Number of pages	13
Journal	Journal of Infection and Chemotherapy
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.jiac.2023.04.008
State	Published - 2023/08

Keywords

Antimicrobial resistance
Antimicrobial susceptibility testing
Bacterial respiratory pathogens
Pneumonia
β-lactamase

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2023.04.008

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Tokimatsu, I., Matsumoto, T., Tsukada, H., Fujikura, Y., Miki, M., Morinaga, Y., Sato, J., Wakamura, T., Kiyota, H., Tateda, K., Yanagisawa, H., Sasaki, T., Ikeda, H., Horikawa, H., Takahashi, H., Seki, M., Mori, Y., Takeda, H., Kurai, D., ... Shinzato, T. (2023). Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility. Journal of Infection and Chemotherapy, 29(8), 731-743. https://doi.org/10.1016/j.jiac.2023.04.008

Tokimatsu, Issei ; Matsumoto, Tetsuya ; Tsukada, Hiroki et al. / Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020 : General view of the pathogens' antibacterial susceptibility. In: Journal of Infection and Chemotherapy. 2023 ; Vol. 29, No. 8. pp. 731-743.

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title = "Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility",

abstract = "The trends and prevalence of antimicrobial susceptibility of pathogens vary by country, region, and time. Long-term regular surveillance is required to investigate trends in the antimicrobial resistance of various isolated bacterial pathogens. We report the results of a nationwide surveillance on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology. The isolates were collected from clinical specimens obtained from adult patients who visited a collaborating medical facility between June 2019 and December 2020 and were diagnosed with respiratory tract infections by a physician. Antimicrobial susceptibility testing was performed in a centralized laboratory according to the methods recommended by the Clinical and Laboratory Standards Institute. Susceptibility testing was performed for 932 strains (201 Staphylococcus aureus, 158 Streptococcus pneumoniae, 6 S. pyogenes, 136 Haemophilus influenzae, 127 Moraxella catarrhalis, 141 Klebsiella pneumoniae, and 163 Pseudomonas aeruginosa) collected from 32 facilities in Japan. The proportions of methicillin-resistant S. aureus and penicillin-resistant S. pneumoniae were 35.3% and 0%, respectively. In H. influenzae, 16.2% and 16.9% were β-lactamase-producing ampicillin resistant and β-lactamase-negative ampicillin resistant, respectively. Extended-spectrum β-lactamase-producing K. pneumoniae accounted for 5.0% of all K. pneumoniae infections. Carbapenemase-producing K. pneumoniae and multi-drug-resistant P. aeruginosa with metallo-β-lactamase were not detected in this study. This surveillance will be a useful reference for treating respiratory infections in Japan and will provide evidence to enhance the appropriate use of antimicrobial agents.",

keywords = "Antimicrobial resistance, Antimicrobial susceptibility testing, Bacterial respiratory pathogens, Pneumonia, β-lactamase",

author = "Issei Tokimatsu and Tetsuya Matsumoto and Hiroki Tsukada and Yuji Fujikura and Makoto Miki and Yoshitomo Morinaga and Junko Sato and Tomotaro Wakamura and Hiroshi Kiyota and Kazuhiro Tateda and Hideji Yanagisawa and Takaaki Sasaki and Hideki Ikeda and Hiroshi Horikawa and Hiroshi Takahashi and Masafumi Seki and Yoshiaki Mori and Hiroaki Takeda and Daisuke Kurai and Naoki Hasegawa and Yoshifumi Uwamino and Makoto Kudo and Masaki Yamamoto and Yuko Nagano and Sakika Nomura and Takafumi Tetsuka and Miyuki Hosokai and Nobuki Aoki and Yoshihiro Yamamoto and Yoshitsugu Iinuma and Hiroshige Mikamo and Hiroyuki Suematsu and Takaya Maruyama and Atsushi Kawabata and Yoshiko Sugaki and Atsushi Nakamura and Yasunori Fujikawa and Tatsuya Fukumori and Akira Ukimura and Hiroshi Kakeya and Makoto Niki and Koichiro Yoshida and Yoshihiro Kobashi and Hirokazu Tokuyasu and Kazuhiro Yatera and Hiroaki Ikegami and Masaki Fujita and Takemasa Matsumoto and Katsunori Yanagihara and Junichi Matsuda and Kazufumi Hiramatsu and Takashi Shinzato",

note = "Publisher Copyright: {\textcopyright} 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control",

year = "2023",

month = aug,

doi = "10.1016/j.jiac.2023.04.008",

language = "英語",

volume = "29",

pages = "731--743",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier B.V.",

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Tokimatsu, I, Matsumoto, T, Tsukada, H, Fujikura, Y, Miki, M, Morinaga, Y, Sato, J, Wakamura, T, Kiyota, H, Tateda, K, Yanagisawa, H, Sasaki, T, Ikeda, H, Horikawa, H, Takahashi, H, Seki, M, Mori, Y, Takeda, H, Kurai, D, Hasegawa, N, Uwamino, Y, Kudo, M, Yamamoto, M, Nagano, Y, Nomura, S, Tetsuka, T, Hosokai, M, Aoki, N, Yamamoto, Y, Iinuma, Y, Mikamo, H, Suematsu, H, Maruyama, T, Kawabata, A, Sugaki, Y, Nakamura, A, Fujikawa, Y, Fukumori, T, Ukimura, A, Kakeya, H, Niki, M, Yoshida, K, Kobashi, Y, Tokuyasu, H, Yatera, K, Ikegami, H, Fujita, M, Matsumoto, T, Yanagihara, K, Matsuda, J, Hiramatsu, K & Shinzato, T 2023, 'Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility', Journal of Infection and Chemotherapy, vol. 29, no. 8, pp. 731-743. https://doi.org/10.1016/j.jiac.2023.04.008

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility. / Tokimatsu, Issei; Matsumoto, Tetsuya; Tsukada, Hiroki et al.
In: Journal of Infection and Chemotherapy, Vol. 29, No. 8, 08.2023, p. 731-743.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020

T2 - General view of the pathogens' antibacterial susceptibility

AU - Tokimatsu, Issei

AU - Matsumoto, Tetsuya

AU - Tsukada, Hiroki

AU - Fujikura, Yuji

AU - Miki, Makoto

AU - Morinaga, Yoshitomo

AU - Sato, Junko

AU - Wakamura, Tomotaro

AU - Kiyota, Hiroshi

AU - Tateda, Kazuhiro

AU - Yanagisawa, Hideji

AU - Sasaki, Takaaki

AU - Ikeda, Hideki

AU - Horikawa, Hiroshi

AU - Takahashi, Hiroshi

AU - Seki, Masafumi

AU - Mori, Yoshiaki

AU - Takeda, Hiroaki

AU - Kurai, Daisuke

AU - Hasegawa, Naoki

AU - Uwamino, Yoshifumi

AU - Kudo, Makoto

AU - Yamamoto, Masaki

AU - Nagano, Yuko

AU - Nomura, Sakika

AU - Tetsuka, Takafumi

AU - Hosokai, Miyuki

AU - Aoki, Nobuki

AU - Yamamoto, Yoshihiro

AU - Iinuma, Yoshitsugu

AU - Mikamo, Hiroshige

AU - Suematsu, Hiroyuki

AU - Maruyama, Takaya

AU - Kawabata, Atsushi

AU - Sugaki, Yoshiko

AU - Nakamura, Atsushi

AU - Fujikawa, Yasunori

AU - Fukumori, Tatsuya

AU - Ukimura, Akira

AU - Kakeya, Hiroshi

AU - Niki, Makoto

AU - Yoshida, Koichiro

AU - Kobashi, Yoshihiro

AU - Tokuyasu, Hirokazu

AU - Yatera, Kazuhiro

AU - Ikegami, Hiroaki

AU - Fujita, Masaki

AU - Matsumoto, Takemasa

AU - Yanagihara, Katsunori

AU - Matsuda, Junichi

AU - Hiramatsu, Kazufumi

AU - Shinzato, Takashi

PY - 2023/8

Y1 - 2023/8

N2 - The trends and prevalence of antimicrobial susceptibility of pathogens vary by country, region, and time. Long-term regular surveillance is required to investigate trends in the antimicrobial resistance of various isolated bacterial pathogens. We report the results of a nationwide surveillance on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology. The isolates were collected from clinical specimens obtained from adult patients who visited a collaborating medical facility between June 2019 and December 2020 and were diagnosed with respiratory tract infections by a physician. Antimicrobial susceptibility testing was performed in a centralized laboratory according to the methods recommended by the Clinical and Laboratory Standards Institute. Susceptibility testing was performed for 932 strains (201 Staphylococcus aureus, 158 Streptococcus pneumoniae, 6 S. pyogenes, 136 Haemophilus influenzae, 127 Moraxella catarrhalis, 141 Klebsiella pneumoniae, and 163 Pseudomonas aeruginosa) collected from 32 facilities in Japan. The proportions of methicillin-resistant S. aureus and penicillin-resistant S. pneumoniae were 35.3% and 0%, respectively. In H. influenzae, 16.2% and 16.9% were β-lactamase-producing ampicillin resistant and β-lactamase-negative ampicillin resistant, respectively. Extended-spectrum β-lactamase-producing K. pneumoniae accounted for 5.0% of all K. pneumoniae infections. Carbapenemase-producing K. pneumoniae and multi-drug-resistant P. aeruginosa with metallo-β-lactamase were not detected in this study. This surveillance will be a useful reference for treating respiratory infections in Japan and will provide evidence to enhance the appropriate use of antimicrobial agents.

AB - The trends and prevalence of antimicrobial susceptibility of pathogens vary by country, region, and time. Long-term regular surveillance is required to investigate trends in the antimicrobial resistance of various isolated bacterial pathogens. We report the results of a nationwide surveillance on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology. The isolates were collected from clinical specimens obtained from adult patients who visited a collaborating medical facility between June 2019 and December 2020 and were diagnosed with respiratory tract infections by a physician. Antimicrobial susceptibility testing was performed in a centralized laboratory according to the methods recommended by the Clinical and Laboratory Standards Institute. Susceptibility testing was performed for 932 strains (201 Staphylococcus aureus, 158 Streptococcus pneumoniae, 6 S. pyogenes, 136 Haemophilus influenzae, 127 Moraxella catarrhalis, 141 Klebsiella pneumoniae, and 163 Pseudomonas aeruginosa) collected from 32 facilities in Japan. The proportions of methicillin-resistant S. aureus and penicillin-resistant S. pneumoniae were 35.3% and 0%, respectively. In H. influenzae, 16.2% and 16.9% were β-lactamase-producing ampicillin resistant and β-lactamase-negative ampicillin resistant, respectively. Extended-spectrum β-lactamase-producing K. pneumoniae accounted for 5.0% of all K. pneumoniae infections. Carbapenemase-producing K. pneumoniae and multi-drug-resistant P. aeruginosa with metallo-β-lactamase were not detected in this study. This surveillance will be a useful reference for treating respiratory infections in Japan and will provide evidence to enhance the appropriate use of antimicrobial agents.

KW - Antimicrobial resistance

KW - Antimicrobial susceptibility testing

KW - Bacterial respiratory pathogens

KW - Pneumonia

KW - β-lactamase

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U2 - 10.1016/j.jiac.2023.04.008

DO - 10.1016/j.jiac.2023.04.008

M3 - 学術論文

C2 - 37116613

AN - SCOPUS:85159119426

SN - 1341-321X

VL - 29

SP - 731

EP - 743

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 8

ER -

Tokimatsu I, Matsumoto T, Tsukada H, Fujikura Y, Miki M, Morinaga Y et al. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility. Journal of Infection and Chemotherapy. 2023 Aug;29(8):731-743. doi: 10.1016/j.jiac.2023.04.008