Mutagenicity of 2,6-dinitrotoluene and its metabolites, and their related compounds in Salmonella typhimurium

Michio Sayama; Masa aki Mori; Tomoko Shirokawa; Masami Inoue; Tatsuro Miyahara; Hiroshi Kozuka

doi:10.1016/0165-7992(89)90017-1

Mutagenicity of 2,6-dinitrotoluene and its metabolites, and their related compounds in Salmonella typhimurium

Michio Sayama^*, Masa aki Mori, Tomoko Shirokawa, Masami Inoue, Tatsuro Miyahara, Hiroshi Kozuka

^*Corresponding author for this work

Life Sciences and Bioengineering

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The mutagenic activities of 2,6-dinitrotoluene (2,6-DNT) and its 6 metabolites, and their 8 related compounds were examined using Salmonella typhimurium strains TA98 and TA100 in the absence or presence of S9 mix. 2,6-DNT itself showed no mutagenicity toward either strain, but 2,6-dinitrobenzaldehyde (2,6-DNBA1), one of the metabolites of 2,6-DNT, showed the highest mutagenic activity in strain TA100. 2,6-DNBA1 was a direct-acting mutagen, not requiring metabolic activation. The other compounds containing nitro groups showed weak or no mutagenic activity. This result suggests that the direct-acting mutagenicity of 2,6-DNBA1 is mainly due to the aldehyde group of the 2,6-DNBA1 molecule.

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	Mutation Research Letters
Volume	226
Issue number	3
DOIs	https://doi.org/10.1016/0165-7992(89)90017-1
State	Published - 1989/07

Keywords

2,6-Dinitrobenzaldehyde
2,6-Dinitrotoluene
Metabolites of 2,6-dinitrotoluene
Mutagenicity
Salmonella typhimurium
Wistar rat

ASJC Scopus subject areas

General Medicine

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10.1016/0165-7992(89)90017-1

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@article{b3149fab38384910a78ab9ac14978c68,

title = "Mutagenicity of 2,6-dinitrotoluene and its metabolites, and their related compounds in Salmonella typhimurium",

abstract = "The mutagenic activities of 2,6-dinitrotoluene (2,6-DNT) and its 6 metabolites, and their 8 related compounds were examined using Salmonella typhimurium strains TA98 and TA100 in the absence or presence of S9 mix. 2,6-DNT itself showed no mutagenicity toward either strain, but 2,6-dinitrobenzaldehyde (2,6-DNBA1), one of the metabolites of 2,6-DNT, showed the highest mutagenic activity in strain TA100. 2,6-DNBA1 was a direct-acting mutagen, not requiring metabolic activation. The other compounds containing nitro groups showed weak or no mutagenic activity. This result suggests that the direct-acting mutagenicity of 2,6-DNBA1 is mainly due to the aldehyde group of the 2,6-DNBA1 molecule.",

keywords = "2,6-Dinitrobenzaldehyde, 2,6-Dinitrotoluene, Metabolites of 2,6-dinitrotoluene, Mutagenicity, Salmonella typhimurium, Wistar rat",

author = "Michio Sayama and Mori, {Masa aki} and Tomoko Shirokawa and Masami Inoue and Tatsuro Miyahara and Hiroshi Kozuka",

year = "1989",

month = jul,

doi = "10.1016/0165-7992(89)90017-1",

language = "英語",

volume = "226",

pages = "181--184",

journal = "Mutation Research Letters",

issn = "0165-7992",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Mutagenicity of 2,6-dinitrotoluene and its metabolites, and their related compounds in Salmonella typhimurium

AU - Sayama, Michio

AU - Mori, Masa aki

AU - Shirokawa, Tomoko

AU - Inoue, Masami

AU - Miyahara, Tatsuro

AU - Kozuka, Hiroshi

PY - 1989/7

Y1 - 1989/7

N2 - The mutagenic activities of 2,6-dinitrotoluene (2,6-DNT) and its 6 metabolites, and their 8 related compounds were examined using Salmonella typhimurium strains TA98 and TA100 in the absence or presence of S9 mix. 2,6-DNT itself showed no mutagenicity toward either strain, but 2,6-dinitrobenzaldehyde (2,6-DNBA1), one of the metabolites of 2,6-DNT, showed the highest mutagenic activity in strain TA100. 2,6-DNBA1 was a direct-acting mutagen, not requiring metabolic activation. The other compounds containing nitro groups showed weak or no mutagenic activity. This result suggests that the direct-acting mutagenicity of 2,6-DNBA1 is mainly due to the aldehyde group of the 2,6-DNBA1 molecule.

AB - The mutagenic activities of 2,6-dinitrotoluene (2,6-DNT) and its 6 metabolites, and their 8 related compounds were examined using Salmonella typhimurium strains TA98 and TA100 in the absence or presence of S9 mix. 2,6-DNT itself showed no mutagenicity toward either strain, but 2,6-dinitrobenzaldehyde (2,6-DNBA1), one of the metabolites of 2,6-DNT, showed the highest mutagenic activity in strain TA100. 2,6-DNBA1 was a direct-acting mutagen, not requiring metabolic activation. The other compounds containing nitro groups showed weak or no mutagenic activity. This result suggests that the direct-acting mutagenicity of 2,6-DNBA1 is mainly due to the aldehyde group of the 2,6-DNBA1 molecule.

KW - 2,6-Dinitrobenzaldehyde

KW - 2,6-Dinitrotoluene

KW - Metabolites of 2,6-dinitrotoluene

KW - Mutagenicity

KW - Salmonella typhimurium

KW - Wistar rat

UR - http://www.scopus.com/inward/record.url?scp=0024405501&partnerID=8YFLogxK

U2 - 10.1016/0165-7992(89)90017-1

DO - 10.1016/0165-7992(89)90017-1

M3 - 学術論文

C2 - 2664501

AN - SCOPUS:0024405501

SN - 0165-7992

VL - 226

SP - 181

EP - 184

JO - Mutation Research Letters

JF - Mutation Research Letters

IS - 3

ER -

Mutagenicity of 2,6-dinitrotoluene and its metabolites, and their related compounds in Salmonella typhimurium

Abstract

Keywords

ASJC Scopus subject areas

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