Muse cell: A new paradigm for cell therapy and regenerative homeostasis in ischemic stroke

Satoshi Kuroda*, Masaki Koh, Emiko Hori, Yumiko Hayakawa, Takuya Akai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

11 Scopus citations

Abstract

Multilineage-differentiating stress enduring (Muse) cells are one of the most promising donor cells for cell therapy against ischemic stroke, because they can differentiate into any type of cells constructing the central nervous system (CNS), including the neurons. They can easily be isolated from the bone marrow stromal cells (BMSCs), which may also contribute to functional recovery after ischemic stroke as donor cells. In this chapter, we concisely review their biological features and then future perspective of Muse cell transplantation for ischemic stroke. In addition, we briefly refer to the surprising role of Muse cells to maintain the homeostasis in the living body under both physiological and pathological conditions.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages187-198
Number of pages12
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1103
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Bone marrow
  • Clinical trial
  • Ischemic stroke
  • Stem cell
  • Transplantation

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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