Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum

Mami Tokunaga; Sohachi Nanjo; Hiroki Yoshita; Haruka Fujinami; Tohru Watanabe; Yoko Ishii; Saito Kobayashi; Momoko Akashi; Hiroaki Takagi; Hiroshi Mihara; Shinya Kajiura; Takayuki Ando; Isaya Hashimoto; Shozo Hojo; Tomoyuki Okumura; Toshiro Sugiyama

doi:10.2169/internalmedicine.0229-17

Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum

Mami Tokunaga, Sohachi Nanjo^*, Hiroki Yoshita, Haruka Fujinami, Tohru Watanabe, Yoko Ishii, Saito Kobayashi, Momoko Akashi, Hiroaki Takagi, Hiroshi Mihara, Shinya Kajiura, Takayuki Ando, Isaya Hashimoto, Shozo Hojo, Tomoyuki Okumura, Toshiro Sugiyama

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.

Original language	English
Pages (from-to)	1719-1723
Number of pages	5
Journal	Internal Medicine
Volume	57
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.0229-17
State	Published - 2018

Keywords

C-kit mutation
Multiple gists

ASJC Scopus subject areas

Internal Medicine

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Tokunaga, M., Nanjo, S., Yoshita, H., Fujinami, H., Watanabe, T., Ishii, Y., Kobayashi, S., Akashi, M., Takagi, H., Mihara, H., Kajiura, S., Ando, T., Hashimoto, I., Hojo, S., Okumura, T., & Sugiyama, T. (2018). Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum. Internal Medicine, 57(12), 1719-1723. https://doi.org/10.2169/internalmedicine.0229-17

@article{62ddd155ec5a4a0184bb27fa329042c5,

title = "Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum",

abstract = "A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.",

keywords = "C-kit mutation, Multiple gists",

author = "Mami Tokunaga and Sohachi Nanjo and Hiroki Yoshita and Haruka Fujinami and Tohru Watanabe and Yoko Ishii and Saito Kobayashi and Momoko Akashi and Hiroaki Takagi and Hiroshi Mihara and Shinya Kajiura and Takayuki Ando and Isaya Hashimoto and Shozo Hojo and Tomoyuki Okumura and Toshiro Sugiyama",

note = "Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Internal Medicine.",

year = "2018",

doi = "10.2169/internalmedicine.0229-17",

language = "英語",

volume = "57",

pages = "1719--1723",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "12",

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Tokunaga, M, Nanjo, S, Yoshita, H, Fujinami, H , Watanabe, T, Ishii, Y, Kobayashi, S, Akashi, M, Takagi, H, Mihara, H, Kajiura, S , Ando, T , Hashimoto, I, Hojo, S, Okumura, T & Sugiyama, T 2018, 'Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum', Internal Medicine, vol. 57, no. 12, pp. 1719-1723. https://doi.org/10.2169/internalmedicine.0229-17

TY - JOUR

T1 - Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum

AU - Tokunaga, Mami

AU - Nanjo, Sohachi

AU - Yoshita, Hiroki

AU - Fujinami, Haruka

AU - Watanabe, Tohru

AU - Ishii, Yoko

AU - Kobayashi, Saito

AU - Akashi, Momoko

AU - Takagi, Hiroaki

AU - Mihara, Hiroshi

AU - Kajiura, Shinya

AU - Ando, Takayuki

AU - Hashimoto, Isaya

AU - Hojo, Shozo

AU - Okumura, Tomoyuki

AU - Sugiyama, Toshiro

PY - 2018

Y1 - 2018

N2 - A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.

AB - A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.

KW - C-kit mutation

KW - Multiple gists

UR - http://www.scopus.com/inward/record.url?scp=85048637904&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.0229-17

DO - 10.2169/internalmedicine.0229-17

M3 - 学術論文

C2 - 29434135

AN - SCOPUS:85048637904

SN - 0918-2918

VL - 57

SP - 1719

EP - 1723

JO - Internal Medicine

JF - Internal Medicine

IS - 12

ER -

Multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum

Abstract

Keywords

ASJC Scopus subject areas

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