Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat

Shigeru Amano; Masaru Ikeda; Shuji Uemura; Junya Fukuoka; Atsushi Tsuji; Masakiyo Sasahara; Yoneko Hayase; Fumitada Hazama

doi:10.1016/S0006-8993(99)01505-X

Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat

Shigeru Amano^*, Masaru Ikeda, Shuji Uemura, Junya Fukuoka, Atsushi Tsuji, Masakiyo Sasahara, Yoneko Hayase, Fumitada Hazama

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We examined the correlation between seizure activity and development of mossy fiber sprouting in the hippocampal formation using Timm staining in a newly developed Ihara epileptic rat (IER). The sprouting of mossy fibers were clearly shown in the inner molecular portion of the dentate gyms and in the stratum oriens of CA3 pyramidal cell layer with repeated seizures. A positive correlation between the frequency of generalized tonic and clonic convulsions and the Timm staining score in molecular layer of dentate gyrus was revealed. Sprouting of mossy fiber in IER seems to be linked with seizure activities resulting from epileptic bursts, not to the genetic mutation.

Original language	English
Pages (from-to)	214-218
Number of pages	5
Journal	Brain Research
Volume	834
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01505-X
State	Published - 1999/07/10

Keywords

Epilepsy
Ihara epileptic rat
Limbic-like seizure
Mossy fiber sprouting
Neuronal plasticity

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01505-X

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title = "Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat",

abstract = "We examined the correlation between seizure activity and development of mossy fiber sprouting in the hippocampal formation using Timm staining in a newly developed Ihara epileptic rat (IER). The sprouting of mossy fibers were clearly shown in the inner molecular portion of the dentate gyms and in the stratum oriens of CA3 pyramidal cell layer with repeated seizures. A positive correlation between the frequency of generalized tonic and clonic convulsions and the Timm staining score in molecular layer of dentate gyrus was revealed. Sprouting of mossy fiber in IER seems to be linked with seizure activities resulting from epileptic bursts, not to the genetic mutation.",

keywords = "Epilepsy, Ihara epileptic rat, Limbic-like seizure, Mossy fiber sprouting, Neuronal plasticity",

author = "Shigeru Amano and Masaru Ikeda and Shuji Uemura and Junya Fukuoka and Atsushi Tsuji and Masakiyo Sasahara and Yoneko Hayase and Fumitada Hazama",

note = "Funding Information: Thanks are due to Mr. K. Ishibashi and Miss K. Sawaguchi for animal maintenance. This work was supported by a Grand-in-Aid for Science Research from the Ministry of Education, Science and Culture of Japan (No. 08680815), from the Ministry of Health and Wealth grant project on human genome analysis of Japan, and from the Japan Epilepsy Research Foundation.",

year = "1999",

month = jul,

day = "10",

doi = "10.1016/S0006-8993(99)01505-X",

language = "英語",

volume = "834",

pages = "214--218",

journal = "Brain Research",

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TY - JOUR

T1 - Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat

AU - Amano, Shigeru

AU - Ikeda, Masaru

AU - Uemura, Shuji

AU - Fukuoka, Junya

AU - Tsuji, Atsushi

AU - Sasahara, Masakiyo

AU - Hayase, Yoneko

AU - Hazama, Fumitada

N1 - Funding Information: Thanks are due to Mr. K. Ishibashi and Miss K. Sawaguchi for animal maintenance. This work was supported by a Grand-in-Aid for Science Research from the Ministry of Education, Science and Culture of Japan (No. 08680815), from the Ministry of Health and Wealth grant project on human genome analysis of Japan, and from the Japan Epilepsy Research Foundation.

PY - 1999/7/10

Y1 - 1999/7/10

N2 - We examined the correlation between seizure activity and development of mossy fiber sprouting in the hippocampal formation using Timm staining in a newly developed Ihara epileptic rat (IER). The sprouting of mossy fibers were clearly shown in the inner molecular portion of the dentate gyms and in the stratum oriens of CA3 pyramidal cell layer with repeated seizures. A positive correlation between the frequency of generalized tonic and clonic convulsions and the Timm staining score in molecular layer of dentate gyrus was revealed. Sprouting of mossy fiber in IER seems to be linked with seizure activities resulting from epileptic bursts, not to the genetic mutation.

AB - We examined the correlation between seizure activity and development of mossy fiber sprouting in the hippocampal formation using Timm staining in a newly developed Ihara epileptic rat (IER). The sprouting of mossy fibers were clearly shown in the inner molecular portion of the dentate gyms and in the stratum oriens of CA3 pyramidal cell layer with repeated seizures. A positive correlation between the frequency of generalized tonic and clonic convulsions and the Timm staining score in molecular layer of dentate gyrus was revealed. Sprouting of mossy fiber in IER seems to be linked with seizure activities resulting from epileptic bursts, not to the genetic mutation.

KW - Epilepsy

KW - Ihara epileptic rat

KW - Limbic-like seizure

KW - Mossy fiber sprouting

KW - Neuronal plasticity

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U2 - 10.1016/S0006-8993(99)01505-X

DO - 10.1016/S0006-8993(99)01505-X

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AN - SCOPUS:0033542755

SN - 0006-8993

VL - 834

SP - 214

EP - 218

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat

Abstract

Keywords

ASJC Scopus subject areas

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