TY - JOUR
T1 - Molecular mechanisms of natural compounds in cell death induction and sensitization to chemotherapeutic drugs in lung cancer
AU - Wattanathamsan, Onsurang
AU - Hayakawa, Yoshihiro
AU - Pongrakhananon, Varisa
N1 - Publisher Copyright:
© 2019 John Wiley & Sons, Ltd.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Cancer remains one of the leading causes of death worldwide, especially lung cancer. Chemotherapeutic drugs are commonly used for lung cancer treatment; nonetheless, undesirable side effects and drug resistance remain major challenges for therapeutic success. Therefore, harmless and effective treatments against lung cancer are urgently required. The use of natural phytochemical products, in single or combinatorial therapy, is an emerging strategy for prevention and cure of cancer because of the various remarkable anticancer properties of these compounds. Cell death, which primarily occurs via apoptosis and nonapoptotic mechanisms (necrosis, autophagy, and cellular senescence), is one of the antineoplastic effects of natural compounds. In this review, we highlight representative plant-derived compounds with cancer chemopreventive and sensitizing effects in combination with chemotherapeutic drugs with various cell death-inducing mechanisms. Relevant molecular mechanisms implicated in the pharmacological effects of these natural compounds are discussed. Overall, this review provides a reference and new perspective for application of phytochemical agents as potential anti-lung cancer drugs for further cancer drug research and development.
AB - Cancer remains one of the leading causes of death worldwide, especially lung cancer. Chemotherapeutic drugs are commonly used for lung cancer treatment; nonetheless, undesirable side effects and drug resistance remain major challenges for therapeutic success. Therefore, harmless and effective treatments against lung cancer are urgently required. The use of natural phytochemical products, in single or combinatorial therapy, is an emerging strategy for prevention and cure of cancer because of the various remarkable anticancer properties of these compounds. Cell death, which primarily occurs via apoptosis and nonapoptotic mechanisms (necrosis, autophagy, and cellular senescence), is one of the antineoplastic effects of natural compounds. In this review, we highlight representative plant-derived compounds with cancer chemopreventive and sensitizing effects in combination with chemotherapeutic drugs with various cell death-inducing mechanisms. Relevant molecular mechanisms implicated in the pharmacological effects of these natural compounds are discussed. Overall, this review provides a reference and new perspective for application of phytochemical agents as potential anti-lung cancer drugs for further cancer drug research and development.
KW - chemosensitization
KW - chemotherapeutic drugs
KW - lung cancer
KW - mechanism of cell death
KW - natural compounds
UR - http://www.scopus.com/inward/record.url?scp=85068752585&partnerID=8YFLogxK
U2 - 10.1002/ptr.6422
DO - 10.1002/ptr.6422
M3 - 総説
C2 - 31293008
AN - SCOPUS:85068752585
SN - 0951-418X
VL - 33
SP - 2531
EP - 2547
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 10
ER -