TY - JOUR
T1 - Modeling of a possible evolutional process from a ribozyme to a catalytic RNP.
AU - Ikawa, Yoshiya
AU - Tsuda, Kentaro
AU - Matsumura, Shigeyoshi
AU - Atsumi, Shota
AU - Inoue, Tan
PY - 2002
Y1 - 2002
N2 - A model process for molecular evolution from an RNA enzyme to a catalytic RNA-protein complex (RNP) is proposed. In the model, one RNA-RNA interaction in the enzyme is replaced by an RNA-protein interaction via an intermediary state where the original RNA-RNA and newly introduced RNA-protein interaction co-exist. To test the model, a catalytic RNP was designed and examined by employing the Tetrahymena ribozyme.
AB - A model process for molecular evolution from an RNA enzyme to a catalytic RNA-protein complex (RNP) is proposed. In the model, one RNA-RNA interaction in the enzyme is replaced by an RNA-protein interaction via an intermediary state where the original RNA-RNA and newly introduced RNA-protein interaction co-exist. To test the model, a catalytic RNP was designed and examined by employing the Tetrahymena ribozyme.
UR - http://www.scopus.com/inward/record.url?scp=0041317570&partnerID=8YFLogxK
U2 - 10.1093/nass/2.1.119
DO - 10.1093/nass/2.1.119
M3 - 学術論文
C2 - 12903134
AN - SCOPUS:0041317570
SP - 119
EP - 120
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 2
ER -