Miniature surface-plasmon resonance immunosensors - Rapid and repetitive procedure

Masayasu Suzuki; Fumihiko Ozawa; Wakako Sugimoto; Shuji Aso

doi:10.1007/s00216-001-1209-3

Miniature surface-plasmon resonance immunosensors - Rapid and repetitive procedure

Masayasu Suzuki^*, Fumihiko Ozawa, Wakako Sugimoto, Shuji Aso

^*Corresponding author for this work

Electric and Electronic Engineering

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A "regenerable" immunosensor has also been developed for this reason.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	Fresenius' Journal of Analytical Chemistry
Volume	372
Issue number	2
DOIs	https://doi.org/10.1007/s00216-001-1209-3
State	Published - 2002

Keywords

Biosensor
Human IgG
Immunosensor
Miniaturization
SPR

ASJC Scopus subject areas

Biochemistry

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10.1007/s00216-001-1209-3

Cite this

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abstract = "Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A {"}regenerable{"} immunosensor has also been developed for this reason.",

keywords = "Biosensor, Human IgG, Immunosensor, Miniaturization, SPR",

author = "Masayasu Suzuki and Fumihiko Ozawa and Wakako Sugimoto and Shuji Aso",

note = "Funding Information: Acknowledgements This work was partially supported by the Research for the Future Program of JSPS, Regional Science Promoter (RSP) Program and Grant-in-Aid for Scientific Research on Priority Area (No.296) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.",

year = "2002",

doi = "10.1007/s00216-001-1209-3",

language = "英語",

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T1 - Miniature surface-plasmon resonance immunosensors - Rapid and repetitive procedure

AU - Suzuki, Masayasu

AU - Ozawa, Fumihiko

AU - Sugimoto, Wakako

AU - Aso, Shuji

N1 - Funding Information: Acknowledgements This work was partially supported by the Research for the Future Program of JSPS, Regional Science Promoter (RSP) Program and Grant-in-Aid for Scientific Research on Priority Area (No.296) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

PY - 2002

Y1 - 2002

N2 - Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A "regenerable" immunosensor has also been developed for this reason.

AB - Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A "regenerable" immunosensor has also been developed for this reason.

KW - Biosensor

KW - Human IgG

KW - Immunosensor

KW - Miniaturization

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AN - SCOPUS:0036253047

SN - 0937-0633

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JO - Fresenius' Journal of Analytical Chemistry

JF - Fresenius' Journal of Analytical Chemistry

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Miniature surface-plasmon resonance immunosensors - Rapid and repetitive procedure

Abstract

Keywords

ASJC Scopus subject areas

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