@article{aa5c344f6b524ea9b1f2c43f108c2cd8,
title = "Midline brain structures in teenagers with first-presentation borderline personality disorder",
abstract = "Brain morphologic changes have been reported in borderline personality disorder (BPD), but it remains largely unknown whether BPD is associated with midline brain abnormalities. We used magnetic resonance imaging to investigate the length of the adhesio interthalamica (AI) and cavum septum pellucidum (CSP) as well as third ventricular volume in 20 teenagers with first-presentation BPD and 20 healthy controls. While the CSP length did not differ between the groups, the AI was significantly shorter in BPD patients than in controls. Furthermore, the BPD patients had a significantly larger third ventricle than controls. These preliminary findings suggest that ongoing neuroimaging studies should further evaluate a potential involvement of midline brain structures in the pathogenesis of BPD.",
keywords = "Adhesio interthalamica, Borderline personality disorder, Cavum septum pellucidum, Thalamus, Third ventricle",
author = "Tsutomu Takahashi and Chanen, {Andrew M.} and Wood, {Stephen J.} and Mark Walterfang and Harding, {Ian H.} and Murat Y{\"u}cel and Kazue Nakamura and McGorry, {Patrick D.} and Michio Suzuki and Dennis Velakoulis and Christos Pantelis",
note = "Funding Information: The authors thank the staff of the HYPE Clinic at ORYGEN Youth Health. Thanks are also due to Ms. Caroline Weinstein, A/Prof. Warrick Brewer and Ms. Deidre Smith for assistance with data collection. This study was supported in part by grants 98-0198 from the Victoria Health Promotion Foundation, Melbourne, Australia and grant 990748 from the National Health and Medical Research Council (NHMRC), Canberra, Australia. ORYGEN Research Centre is supported by an unrestricted grant from the Colonial Foundation, Melbourne, Australia. Neuroimaging analysis was facilitated by the Melbourne Neuropsychiatry Centre's Imaging Laboratory, managed by Ms. Bridget Soulsby and supported by Neurosciences Victoria. Dr. Wood is currently supported by an NHMRC Clinical Career Developmental Award and a NARSAD Young Investigator Award. Dr. Y{\"u}cel is supported by NHMRC Clinical Career Development Grant 509345. Dr. Takahashi was supported to undertake this work by a Grant-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science, and a Research Grant (17-2, 18-6) for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan.",
year = "2009",
month = aug,
day = "1",
doi = "10.1016/j.pnpbp.2009.03.035",
language = "英語",
volume = "33",
pages = "842--846",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "5",
}