Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat

N. Tanaka; N. Sekiya; M. Hattori; H. Goto; N. Shibahara; Y. Shimada; K. Terasawa

doi:10.1078/094471103321659816

Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat

N. Tanaka, N. Sekiya^*, M. Hattori, H. Goto, N. Shibahara, Y. Shimada, K. Terasawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Using a high-performance liquid chromatographic method and mass spectrometry analysis, we successfully measured the absorption of orally administered procyanidin B-2 and procyanidin B-3 isolated from Cinnamonomi cortex (the bark of Cinnamomum cassia Blume) in the rat plasma. This method used a TSK- GEL ODS-80TS column, two solvents (A: 0.01% acetic acid; B: methanol with 0.01 % acetic acid) in a linear gradient at a flow-rate of 1.0 ml/min, and fluorescence detection at excitation and emission wavelengths of 220 and 327 nm.

Original language	English
Pages (from-to)	122-126
Number of pages	5
Journal	Phytomedicine
Volume	10
Issue number	2-3
DOIs	https://doi.org/10.1078/094471103321659816
State	Published - 2003/03

Keywords

Cinnamonomi cortex
Fluorescence detection
Ion spray mass spectrometry
Oral absorption in rats
Procyanidin B-2
Procyanidin B-3

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

Access to Document

10.1078/094471103321659816

Cite this

@article{00c2490515d54a3b934d1e8bfef903c1,

title = "Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat",

abstract = "Using a high-performance liquid chromatographic method and mass spectrometry analysis, we successfully measured the absorption of orally administered procyanidin B-2 and procyanidin B-3 isolated from Cinnamonomi cortex (the bark of Cinnamomum cassia Blume) in the rat plasma. This method used a TSK- GEL ODS-80TS column, two solvents (A: 0.01% acetic acid; B: methanol with 0.01 % acetic acid) in a linear gradient at a flow-rate of 1.0 ml/min, and fluorescence detection at excitation and emission wavelengths of 220 and 327 nm.",

keywords = "Cinnamonomi cortex, Fluorescence detection, Ion spray mass spectrometry, Oral absorption in rats, Procyanidin B-2, Procyanidin B-3",

author = "N. Tanaka and N. Sekiya and M. Hattori and H. Goto and N. Shibahara and Y. Shimada and K. Terasawa",

note = "Funding Information: This study was supported by a grant-in-aid by Funds for Comprehensive Research on Aging and Health from the Japanese Ministry of Health, Labour and Welfare.",

year = "2003",

month = mar,

doi = "10.1078/094471103321659816",

language = "英語",

volume = "10",

pages = "122--126",

journal = "Phytomedicine",

issn = "0944-7113",

publisher = "Elsevier GmbH",

number = "2-3",

}

TY - JOUR

T1 - Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat

AU - Tanaka, N.

AU - Sekiya, N.

AU - Hattori, M.

AU - Goto, H.

AU - Shibahara, N.

AU - Shimada, Y.

AU - Terasawa, K.

N1 - Funding Information: This study was supported by a grant-in-aid by Funds for Comprehensive Research on Aging and Health from the Japanese Ministry of Health, Labour and Welfare.

PY - 2003/3

Y1 - 2003/3

N2 - Using a high-performance liquid chromatographic method and mass spectrometry analysis, we successfully measured the absorption of orally administered procyanidin B-2 and procyanidin B-3 isolated from Cinnamonomi cortex (the bark of Cinnamomum cassia Blume) in the rat plasma. This method used a TSK- GEL ODS-80TS column, two solvents (A: 0.01% acetic acid; B: methanol with 0.01 % acetic acid) in a linear gradient at a flow-rate of 1.0 ml/min, and fluorescence detection at excitation and emission wavelengths of 220 and 327 nm.

AB - Using a high-performance liquid chromatographic method and mass spectrometry analysis, we successfully measured the absorption of orally administered procyanidin B-2 and procyanidin B-3 isolated from Cinnamonomi cortex (the bark of Cinnamomum cassia Blume) in the rat plasma. This method used a TSK- GEL ODS-80TS column, two solvents (A: 0.01% acetic acid; B: methanol with 0.01 % acetic acid) in a linear gradient at a flow-rate of 1.0 ml/min, and fluorescence detection at excitation and emission wavelengths of 220 and 327 nm.

KW - Cinnamonomi cortex

KW - Fluorescence detection

KW - Ion spray mass spectrometry

KW - Oral absorption in rats

KW - Procyanidin B-2

KW - Procyanidin B-3

UR - http://www.scopus.com/inward/record.url?scp=0037358110&partnerID=8YFLogxK

U2 - 10.1078/094471103321659816

DO - 10.1078/094471103321659816

M3 - 学術論文

C2 - 12725564

AN - SCOPUS:0037358110

SN - 0944-7113

VL - 10

SP - 122

EP - 126

JO - Phytomedicine

JF - Phytomedicine

IS - 2-3

ER -

Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this