Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma

Hisae Honoki; Yukio Kawagishi; Hirofumi Oda; Toshiro Miwa; Minehiko Inomata; Tadashi Fujita; Shoko Matsui; Tatsuhiko Kashii; Muneharu Maruyama; Masashi Kobayashi

Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma

Hisae Honoki^*, Yukio Kawagishi, Hirofumi Oda, Toshiro Miwa, Minehiko Inomata, Tadashi Fujita, Shoko Matsui, Tatsuhiko Kashii, Muneharu Maruyama, Masashi Kobayashi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 68-year-old man was admitted to our hospital because of muscle weakness. A complete medical examination led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS) and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Four courses of chemotherapy (carboplatin + etoposide) and one of radiotherapy with a total dose of 45 Gy to the mediastinum were performed and resulted in a partial response in the SCLC. After the second course of chemotherapy, the serum level of antivoltage-gated Ca2+ channel (VGCC) antibody decreased from 190 pg/ml to 120 pg/ml. Marked improvement of the muscle weakness was recognized only after 3 courses of chemotherapy. The patient, who had had difficulty in standing, recovered enough to be able to climb stairs after 4 courses of chemotherapy. Marked improvement of LEMS was achieved by treatment for small cell lung carcinoma.

Original language	English
Pages (from-to)	331-335
Number of pages	5
Journal	Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume	41
Issue number	5
State	Published - 2003/05

ASJC Scopus subject areas

General Medicine

Cite this

@article{167ed58e27204309b58a324ee92da8ff,

title = "Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma",

abstract = "A 68-year-old man was admitted to our hospital because of muscle weakness. A complete medical examination led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS) and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Four courses of chemotherapy (carboplatin + etoposide) and one of radiotherapy with a total dose of 45 Gy to the mediastinum were performed and resulted in a partial response in the SCLC. After the second course of chemotherapy, the serum level of antivoltage-gated Ca2+ channel (VGCC) antibody decreased from 190 pg/ml to 120 pg/ml. Marked improvement of the muscle weakness was recognized only after 3 courses of chemotherapy. The patient, who had had difficulty in standing, recovered enough to be able to climb stairs after 4 courses of chemotherapy. Marked improvement of LEMS was achieved by treatment for small cell lung carcinoma.",

author = "Hisae Honoki and Yukio Kawagishi and Hirofumi Oda and Toshiro Miwa and Minehiko Inomata and Tadashi Fujita and Shoko Matsui and Tatsuhiko Kashii and Muneharu Maruyama and Masashi Kobayashi",

year = "2003",

month = may,

language = "英語",

volume = "41",

pages = "331--335",

journal = "Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society",

issn = "1343-3490",

publisher = "Nihon Kokyuki Gakkai",

number = "5",

}

TY - JOUR

T1 - Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma

AU - Honoki, Hisae

AU - Kawagishi, Yukio

AU - Oda, Hirofumi

AU - Miwa, Toshiro

AU - Inomata, Minehiko

AU - Fujita, Tadashi

AU - Matsui, Shoko

AU - Kashii, Tatsuhiko

AU - Maruyama, Muneharu

AU - Kobayashi, Masashi

PY - 2003/5

Y1 - 2003/5

N2 - A 68-year-old man was admitted to our hospital because of muscle weakness. A complete medical examination led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS) and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Four courses of chemotherapy (carboplatin + etoposide) and one of radiotherapy with a total dose of 45 Gy to the mediastinum were performed and resulted in a partial response in the SCLC. After the second course of chemotherapy, the serum level of antivoltage-gated Ca2+ channel (VGCC) antibody decreased from 190 pg/ml to 120 pg/ml. Marked improvement of the muscle weakness was recognized only after 3 courses of chemotherapy. The patient, who had had difficulty in standing, recovered enough to be able to climb stairs after 4 courses of chemotherapy. Marked improvement of LEMS was achieved by treatment for small cell lung carcinoma.

AB - A 68-year-old man was admitted to our hospital because of muscle weakness. A complete medical examination led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS) and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Four courses of chemotherapy (carboplatin + etoposide) and one of radiotherapy with a total dose of 45 Gy to the mediastinum were performed and resulted in a partial response in the SCLC. After the second course of chemotherapy, the serum level of antivoltage-gated Ca2+ channel (VGCC) antibody decreased from 190 pg/ml to 120 pg/ml. Marked improvement of the muscle weakness was recognized only after 3 courses of chemotherapy. The patient, who had had difficulty in standing, recovered enough to be able to climb stairs after 4 courses of chemotherapy. Marked improvement of LEMS was achieved by treatment for small cell lung carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0037492621&partnerID=8YFLogxK

M3 - 学術論文

C2 - 12822423

AN - SCOPUS:0037492621

SN - 1343-3490

VL - 41

SP - 331

EP - 335

JO - Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society

JF - Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society

IS - 5

ER -

Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma

Abstract

ASJC Scopus subject areas

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