TY - JOUR
T1 - Lysosomal enzyme activities in the cerebral microvessels in spontaneously and renal hypertensive rats
AU - Yukioka, Naoya
AU - Yamada, Eiji
AU - Sasahara, Masakiyo
AU - Kawai, Jun
AU - Hayase, Yoneko
AU - Amano, Shigeru
AU - Hazama, Fumitada
PY - 1988/8
Y1 - 1988/8
N2 - In an attempt to clarify the role of lysosomal enzymes in the developmental mechanisms of the changes of cerebral microvessels under hypertensive conditions, the activities of acid phosphatase, N-acetyl-β-glucosaminidase, and β-glucuronidase in the isolated microvessels from the cerebral cortex of spontaneously and renal hypertensive rats were biochemically studied. The activities of all the enzymes were higher than those in normotensive control animals, although there was a variation in intensity according to the age and kind of enzymes. The enzyme activities in spontaneously hypertensive rats showed a tendency to increase with advancing age. Hypertension seems to increase activities of lysosomal enzymes in cerebral microvessels, and this activation may in turn play a role in the development of further hypertensive cerebrovascular and cerebral changes.
AB - In an attempt to clarify the role of lysosomal enzymes in the developmental mechanisms of the changes of cerebral microvessels under hypertensive conditions, the activities of acid phosphatase, N-acetyl-β-glucosaminidase, and β-glucuronidase in the isolated microvessels from the cerebral cortex of spontaneously and renal hypertensive rats were biochemically studied. The activities of all the enzymes were higher than those in normotensive control animals, although there was a variation in intensity according to the age and kind of enzymes. The enzyme activities in spontaneously hypertensive rats showed a tendency to increase with advancing age. Hypertension seems to increase activities of lysosomal enzymes in cerebral microvessels, and this activation may in turn play a role in the development of further hypertensive cerebrovascular and cerebral changes.
UR - http://www.scopus.com/inward/record.url?scp=0023785311&partnerID=8YFLogxK
U2 - 10.1016/0014-4800(88)90025-1
DO - 10.1016/0014-4800(88)90025-1
M3 - 学術論文
C2 - 3396663
AN - SCOPUS:0023785311
SN - 0014-4800
VL - 49
SP - 111
EP - 117
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 1
ER -