TY - JOUR
T1 - Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells
AU - Chang, Hang
AU - Wang, Yuwei
AU - Gao, Xue
AU - Song, Zehai
AU - Awale, Suresh
AU - Han, Na
AU - Liu, Zhihui
AU - Yin, Jun
N1 - Publisher Copyright:
© 2017
PY - 2017/9
Y1 - 2017/9
N2 - Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5′,5′-(+)-matairesinol (5), bis-5,5′-(+)-matairesinol (6), together with 20 known compounds (7–26) were isolated from the CH2Cl2 extract of roots of Wikstroemia indica. Structures of compounds 1–6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compounds 8 and 12 displayed mild preferential cytotoxicity in the nutrient-deprived medium (NDM) and without causing toxicity in normal nutrient-rich conditions.
AB - Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5′,5′-(+)-matairesinol (5), bis-5,5′-(+)-matairesinol (6), together with 20 known compounds (7–26) were isolated from the CH2Cl2 extract of roots of Wikstroemia indica. Structures of compounds 1–6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compounds 8 and 12 displayed mild preferential cytotoxicity in the nutrient-deprived medium (NDM) and without causing toxicity in normal nutrient-rich conditions.
UR - http://www.scopus.com/inward/record.url?scp=85021657871&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2017.06.012
DO - 10.1016/j.fitote.2017.06.012
M3 - 学術論文
C2 - 28629933
AN - SCOPUS:85021657871
SN - 0367-326X
VL - 121
SP - 31
EP - 37
JO - Fitoterapia
JF - Fitoterapia
ER -
