Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Shogo Haraguchi; Masaki Kamata; Takuma Tokita; Kei Ichiro Tashiro; Miku Sato; Mitsuki Nozaki; Mayumi Okamoto-Katsuyama; Isao Shimizu; Guofeng Han; Vishwajit S. Chowdhury; Xiao Feng Lei; Takuro Miyazaki; Joo Ri Kim-Kaneyama; Tomoya Nakamachi; Kouhei Matsuda; Hirokazu Ohtaki; Toshinobu Tokumoto; Tetsuya Tachibana; Akira Miyazaki; Kazuyoshi Tsutsui

doi:10.7554/elife.45306

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Shogo Haraguchi^*, Masaki Kamata, Takuma Tokita, Kei Ichiro Tashiro, Miku Sato, Mitsuki Nozaki, Mayumi Okamoto-Katsuyama, Isao Shimizu, Guofeng Han, Vishwajit S. Chowdhury, Xiao Feng Lei, Takuro Miyazaki, Joo Ri Kim-Kaneyama, Tomoya Nakamachi, Kouhei Matsuda, Hirokazu Ohtaki, Toshinobu Tokumoto, Tetsuya Tachibana, Akira Miyazaki, Kazuyoshi Tsutsui

^*Corresponding author for this work

Program of Biological Science

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death.

Original language	English
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/elife.45306
State	Published - 2019/09

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

Access to Document

10.7554/elife.45306

Cite this

Haraguchi, S., Kamata, M., Tokita, T., Tashiro, K. I., Sato, M., Nozaki, M., Okamoto-Katsuyama, M., Shimizu, I., Han, G., Chowdhury, V. S., Lei, X. F., Miyazaki, T., Kim-Kaneyama, J. R., Nakamachi, T., Matsuda, K., Ohtaki, H., Tokumoto, T., Tachibana, T., Miyazaki, A., & Tsutsui, K. (2019). Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. eLife, 8. https://doi.org/10.7554/elife.45306

@article{5e544d382a744aefbb3d4d5a463b3529,

title = "Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms",

abstract = "The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death.",

author = "Shogo Haraguchi and Masaki Kamata and Takuma Tokita and Tashiro, {Kei Ichiro} and Miku Sato and Mitsuki Nozaki and Mayumi Okamoto-Katsuyama and Isao Shimizu and Guofeng Han and Chowdhury, {Vishwajit S.} and Lei, {Xiao Feng} and Takuro Miyazaki and Kim-Kaneyama, {Joo Ri} and Tomoya Nakamachi and Kouhei Matsuda and Hirokazu Ohtaki and Toshinobu Tokumoto and Tetsuya Tachibana and Akira Miyazaki and Kazuyoshi Tsutsui",

note = "Publisher Copyright: {\textcopyright} Shogo Haraguchi",

year = "2019",

month = sep,

doi = "10.7554/elife.45306",

language = "英語",

volume = "8",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Ltd",

}

Haraguchi, S, Kamata, M, Tokita, T, Tashiro, KI, Sato, M, Nozaki, M, Okamoto-Katsuyama, M, Shimizu, I, Han, G, Chowdhury, VS, Lei, XF, Miyazaki, T, Kim-Kaneyama, JR, Nakamachi, T , Matsuda, K, Ohtaki, H, Tokumoto, T, Tachibana, T, Miyazaki, A & Tsutsui, K 2019, 'Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms', eLife, vol. 8. https://doi.org/10.7554/elife.45306

TY - JOUR

T1 - Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

AU - Haraguchi, Shogo

AU - Kamata, Masaki

AU - Tokita, Takuma

AU - Tashiro, Kei Ichiro

AU - Sato, Miku

AU - Nozaki, Mitsuki

AU - Okamoto-Katsuyama, Mayumi

AU - Shimizu, Isao

AU - Han, Guofeng

AU - Chowdhury, Vishwajit S.

AU - Lei, Xiao Feng

AU - Miyazaki, Takuro

AU - Kim-Kaneyama, Joo Ri

AU - Nakamachi, Tomoya

AU - Matsuda, Kouhei

AU - Ohtaki, Hirokazu

AU - Tokumoto, Toshinobu

AU - Tachibana, Tetsuya

AU - Miyazaki, Akira

AU - Tsutsui, Kazuyoshi

PY - 2019/9

Y1 - 2019/9

N2 - The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death.

AB - The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death.

UR - http://www.scopus.com/inward/record.url?scp=85073626634&partnerID=8YFLogxK

U2 - 10.7554/elife.45306

DO - 10.7554/elife.45306

M3 - 学術論文

C2 - 31566568

AN - SCOPUS:85073626634

SN - 2050-084X

VL - 8

JO - eLife

JF - eLife

ER -

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this