Left Hypofrontality Correlates with Blunted Affect in Schizophrenia

Michio Suzuki; Masayoshi Kurachi; Yasuhiro Kawasaki; Kiyoko Kiba; Nariyoshi Yamaguchi

doi:10.1111/j.1440-1819.1992.tb00539.x

Left Hypofrontality Correlates with Blunted Affect in Schizophrenia

Michio Suzuki^*, Masayoshi Kurachi, Yasuhiro Kawasaki, Kiyoko Kiba, Nariyoshi Yamaguchi

^*Corresponding author for this work

Neuropsychiatry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Abstract: Regional cerebral blood flow (rCBF) during the resting state was measured using the ¹³³Xe inhalation technique in 39: patients diagnosed as having schizophrenic disorder according to the DSM‐III criteria and 30: age‐ and sex‐matched healthy volunteers. All the patients were receiving neuroleptic medication. The bilateral hemispheric mean flow values in the schizophrenic patients decreased significantly and the relative flow distribution reduced significantly only in the left frontal region compared to the controls. The lower the left frontal blood flow in schizophrenics, the more pronounced were the negative symptoms including blunted aflect, avolition‐apathy and inattention. These results suggest that the negative symptoms in schizophrenics are related to left frontal lobe dysfunction.

Original language	English
Pages (from-to)	653-657
Number of pages	5
Journal	Psychiatry and Clinical Neurosciences
Volume	46
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1819.1992.tb00539.x
State	Published - 1992/09

Keywords

Xe inhalation technique
left hypofrontality
negative symptoms
regional cerebral blood flow
schizophrenia

ASJC Scopus subject areas

General Neuroscience
Neurology
Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1440-1819.1992.tb00539.x

Cite this

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title = "Left Hypofrontality Correlates with Blunted Affect in Schizophrenia",

abstract = "Abstract: Regional cerebral blood flow (rCBF) during the resting state was measured using the 133Xe inhalation technique in 39: patients diagnosed as having schizophrenic disorder according to the DSM‐III criteria and 30: age‐ and sex‐matched healthy volunteers. All the patients were receiving neuroleptic medication. The bilateral hemispheric mean flow values in the schizophrenic patients decreased significantly and the relative flow distribution reduced significantly only in the left frontal region compared to the controls. The lower the left frontal blood flow in schizophrenics, the more pronounced were the negative symptoms including blunted aflect, avolition‐apathy and inattention. These results suggest that the negative symptoms in schizophrenics are related to left frontal lobe dysfunction.",

keywords = "Xe inhalation technique, left hypofrontality, negative symptoms, regional cerebral blood flow, schizophrenia",

author = "Michio Suzuki and Masayoshi Kurachi and Yasuhiro Kawasaki and Kiyoko Kiba and Nariyoshi Yamaguchi",

year = "1992",

month = sep,

doi = "10.1111/j.1440-1819.1992.tb00539.x",

language = "英語",

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journal = "Psychiatry and Clinical Neurosciences",

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T1 - Left Hypofrontality Correlates with Blunted Affect in Schizophrenia

AU - Suzuki, Michio

AU - Kurachi, Masayoshi

AU - Kawasaki, Yasuhiro

AU - Kiba, Kiyoko

AU - Yamaguchi, Nariyoshi

PY - 1992/9

Y1 - 1992/9

N2 - Abstract: Regional cerebral blood flow (rCBF) during the resting state was measured using the 133Xe inhalation technique in 39: patients diagnosed as having schizophrenic disorder according to the DSM‐III criteria and 30: age‐ and sex‐matched healthy volunteers. All the patients were receiving neuroleptic medication. The bilateral hemispheric mean flow values in the schizophrenic patients decreased significantly and the relative flow distribution reduced significantly only in the left frontal region compared to the controls. The lower the left frontal blood flow in schizophrenics, the more pronounced were the negative symptoms including blunted aflect, avolition‐apathy and inattention. These results suggest that the negative symptoms in schizophrenics are related to left frontal lobe dysfunction.

AB - Abstract: Regional cerebral blood flow (rCBF) during the resting state was measured using the 133Xe inhalation technique in 39: patients diagnosed as having schizophrenic disorder according to the DSM‐III criteria and 30: age‐ and sex‐matched healthy volunteers. All the patients were receiving neuroleptic medication. The bilateral hemispheric mean flow values in the schizophrenic patients decreased significantly and the relative flow distribution reduced significantly only in the left frontal region compared to the controls. The lower the left frontal blood flow in schizophrenics, the more pronounced were the negative symptoms including blunted aflect, avolition‐apathy and inattention. These results suggest that the negative symptoms in schizophrenics are related to left frontal lobe dysfunction.

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Left Hypofrontality Correlates with Blunted Affect in Schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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