@article{406d841661d44153a927e949fe4e52c8,
title = "Katorazone, a new yellow pigment with a 2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. IFM 11299",
abstract = "An unusual alkaloid with a 2-azaquinone-phenylhydrazone structure, katorazone (1), and other metabolites were isolated from the ethyl acetate extract of Streptomyces sp. IFM 11299. The chemical structure of katorazone (1) was elucidated by 1D and 2D NMR analyses together with HR-ESI mass spectrometry. Katorazone (1) showed a synergistic effect in combination with TRAIL and decreased the viability of human gastric adenocarcinoma (AGS) cells.",
keywords = "Azaquinone, Phenylhydrazone, Streptomyces",
author = "Abdelfattah, {Mohamed S.} and Kazufumi Toume and Arai, {Midori A.} and Hyuma Masu and Masami Ishibashi",
note = "Funding Information: We are thankful to Professor Tohru Gonoi (Medical Mycology Research Center, Chiba University) for the identification of Streptomyces sp. IFM 11299. The research was supported by Grants in-Aid (22310133 and 23404007) for Scientific Research from the Japan Society for the Promotion of Science (JSPS), a Grant-in-Aid (23102008) for Scientific Research on Innovative Areas {\textquoteleft}Chemical Biology of Natural Products{\textquoteright} from The Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Special Funds for Education and Research (Development of SPECT Probes for Pharmaceutical Innovation) from MEXT, the Iodine Research Project in the Chiba University, and the Asian Core Program (JSPS). M.S. Abdelfattah thanks JSPS for a postdoctoral fellowship (ID No. P09042). ",
year = "2012",
month = jun,
day = "27",
doi = "10.1016/j.tetlet.2012.04.073",
language = "英語",
volume = "53",
pages = "3346--3348",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "26",
}