Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain

Takeshi Uemura; Hisashi Mori; Masayoshi Mishina

doi:10.1016/S0006-291X(02)00900-2

Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain

Takeshi Uemura, Hisashi Mori, Masayoshi Mishina^*

^*Corresponding author for this work

Molecular Neuroscience

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

We identified a novel Golgi apparatus-specific protein with the DHHC zinc finger domain and four putative transmembrane regions, designated as GODZ. The amino acid sequences were highly conserved among mouse and human GODZs and homologous proteins in human, mouse, rat, Drosophila melanogaster, and Caenorhabditis elegans, implying a functional significance of the GODZ protein family. Overexpression of mouse GODZ in COS7 cells suppressed the sorting of the glutamate receptor GluRα1 from the Golgi apparatus. These results suggest that GODZ plays a role in the membrane protein trafficking.

Original language	English
Pages (from-to)	492-496
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	296
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(02)00900-2
State	Published - 2002

Keywords

COS7 cells
DHHC zinc finger domain
Golgi apparatus
Protein trafficking

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(02)00900-2

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title = "Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain",

abstract = "We identified a novel Golgi apparatus-specific protein with the DHHC zinc finger domain and four putative transmembrane regions, designated as GODZ. The amino acid sequences were highly conserved among mouse and human GODZs and homologous proteins in human, mouse, rat, Drosophila melanogaster, and Caenorhabditis elegans, implying a functional significance of the GODZ protein family. Overexpression of mouse GODZ in COS7 cells suppressed the sorting of the glutamate receptor GluRα1 from the Golgi apparatus. These results suggest that GODZ plays a role in the membrane protein trafficking.",

keywords = "COS7 cells, DHHC zinc finger domain, Golgi apparatus, Protein trafficking",

author = "Takeshi Uemura and Hisashi Mori and Masayoshi Mishina",

note = "Funding Information: This work was supported in part by research grants from the Japan Science and Technology Corporation and the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

year = "2002",

doi = "10.1016/S0006-291X(02)00900-2",

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volume = "296",

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journal = "Biochemical and Biophysical Research Communications",

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T1 - Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain

AU - Uemura, Takeshi

AU - Mori, Hisashi

AU - Mishina, Masayoshi

N1 - Funding Information: This work was supported in part by research grants from the Japan Science and Technology Corporation and the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2002

Y1 - 2002

N2 - We identified a novel Golgi apparatus-specific protein with the DHHC zinc finger domain and four putative transmembrane regions, designated as GODZ. The amino acid sequences were highly conserved among mouse and human GODZs and homologous proteins in human, mouse, rat, Drosophila melanogaster, and Caenorhabditis elegans, implying a functional significance of the GODZ protein family. Overexpression of mouse GODZ in COS7 cells suppressed the sorting of the glutamate receptor GluRα1 from the Golgi apparatus. These results suggest that GODZ plays a role in the membrane protein trafficking.

AB - We identified a novel Golgi apparatus-specific protein with the DHHC zinc finger domain and four putative transmembrane regions, designated as GODZ. The amino acid sequences were highly conserved among mouse and human GODZs and homologous proteins in human, mouse, rat, Drosophila melanogaster, and Caenorhabditis elegans, implying a functional significance of the GODZ protein family. Overexpression of mouse GODZ in COS7 cells suppressed the sorting of the glutamate receptor GluRα1 from the Golgi apparatus. These results suggest that GODZ plays a role in the membrane protein trafficking.

KW - COS7 cells

KW - DHHC zinc finger domain

KW - Golgi apparatus

KW - Protein trafficking

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DO - 10.1016/S0006-291X(02)00900-2

M3 - 学術論文

C2 - 12163046

AN - SCOPUS:0036389570

SN - 0006-291X

VL - 296

SP - 492

EP - 496

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain

Abstract

Keywords

ASJC Scopus subject areas

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