Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-γ-dependent suppression of subcutaneous tumor growth

Kazuyoshi Takeda; Mark J. Smyth; Erika Cretney; Yoshihiro Hayakawa; Noriko Yamaguchi; Hideo Yagita; Ko Okumura

doi:10.1006/cimm.2001.1896

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-γ-dependent suppression of subcutaneous tumor growth

Kazuyoshi Takeda^*, Mark J. Smyth, Erika Cretney, Yoshihiro Hayakawa, Noriko Yamaguchi, Hideo Yagita, Ko Okumura

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

Natural killer (NK) cells and interferon- (IFN) γ have been implicated in immune surveillance against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-mediated and IFN-γ-dependent suppression of subcutaneous growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors (L929, LB27.4, and Renca) but not TRAIL-resistant tumors (P815 and B16). Such a protective effect of TRAIL against TRAIL-sensitive tumors was abrogated in NK cell-depleted or IFN-γ-deficient mice. These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors.

Original language	English
Pages (from-to)	194-200
Number of pages	7
Journal	Cellular Immunology
Volume	214
Issue number	2
DOIs	https://doi.org/10.1006/cimm.2001.1896
State	Published - 2001/12/15

Keywords

IFN-γ
NK cells
TRAIL
Tumor growth

ASJC Scopus subject areas

Immunology

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10.1006/cimm.2001.1896

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title = "Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-γ-dependent suppression of subcutaneous tumor growth",

abstract = "Natural killer (NK) cells and interferon- (IFN) γ have been implicated in immune surveillance against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-mediated and IFN-γ-dependent suppression of subcutaneous growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors (L929, LB27.4, and Renca) but not TRAIL-resistant tumors (P815 and B16). Such a protective effect of TRAIL against TRAIL-sensitive tumors was abrogated in NK cell-depleted or IFN-γ-deficient mice. These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors.",

keywords = "IFN-γ, NK cells, TRAIL, Tumor growth",

author = "Kazuyoshi Takeda and Smyth, {Mark J.} and Erika Cretney and Yoshihiro Hayakawa and Noriko Yamaguchi and Hideo Yagita and Ko Okumura",

note = "Funding Information: This work was supported by research grants from the Human Frontier Science Program Organization and the Ministry of Education, Science, and Culture, Japan. M. J. Smyth was also supported by the National Health and Medical Research Council of Australia.",

year = "2001",

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day = "15",

doi = "10.1006/cimm.2001.1896",

language = "英語",

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T1 - Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-γ-dependent suppression of subcutaneous tumor growth

AU - Takeda, Kazuyoshi

AU - Smyth, Mark J.

AU - Cretney, Erika

AU - Hayakawa, Yoshihiro

AU - Yamaguchi, Noriko

AU - Yagita, Hideo

AU - Okumura, Ko

N1 - Funding Information: This work was supported by research grants from the Human Frontier Science Program Organization and the Ministry of Education, Science, and Culture, Japan. M. J. Smyth was also supported by the National Health and Medical Research Council of Australia.

PY - 2001/12/15

Y1 - 2001/12/15

N2 - Natural killer (NK) cells and interferon- (IFN) γ have been implicated in immune surveillance against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-mediated and IFN-γ-dependent suppression of subcutaneous growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors (L929, LB27.4, and Renca) but not TRAIL-resistant tumors (P815 and B16). Such a protective effect of TRAIL against TRAIL-sensitive tumors was abrogated in NK cell-depleted or IFN-γ-deficient mice. These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors.

AB - Natural killer (NK) cells and interferon- (IFN) γ have been implicated in immune surveillance against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-mediated and IFN-γ-dependent suppression of subcutaneous growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors (L929, LB27.4, and Renca) but not TRAIL-resistant tumors (P815 and B16). Such a protective effect of TRAIL against TRAIL-sensitive tumors was abrogated in NK cell-depleted or IFN-γ-deficient mice. These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors.

KW - IFN-γ

KW - NK cells

KW - TRAIL

KW - Tumor growth

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M3 - 学術論文

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AN - SCOPUS:0035894946

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JO - Cellular Immunology

JF - Cellular Immunology

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ER -

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-γ-dependent suppression of subcutaneous tumor growth

Abstract

Keywords

ASJC Scopus subject areas

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