Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation

Kazuhiro Abeyama; Kazunori Kawano; Toshihiro Nakajima; Ikuko Takasaki; Isao Kitajima; Ikuro Maruyama

doi:10.1016/0014-5793(95)00412-3

Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation

Kazuhiro Abeyama, Kazunori Kawano, Toshihiro Nakajima, Ikuko Takasaki, Isao Kitajima, Ikuro Maruyama^*

^*Corresponding author for this work

Member of the Board

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF-κB) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.

Original language	English
Pages (from-to)	298-300
Number of pages	3
Journal	FEBS Letters
Volume	364
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(95)00412-3
State	Published - 1995/05/15

Keywords

Cell redox
Differentiation
Interleukin 6
Ionizing radiation
Nuclear factor κB

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation",

abstract = "The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF-κB) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.",

keywords = "Cell redox, Differentiation, Interleukin 6, Ionizing radiation, Nuclear factor κB",

author = "Kazuhiro Abeyama and Kazunori Kawano and Toshihiro Nakajima and Ikuko Takasaki and Isao Kitajima and Ikuro Maruyama",

year = "1995",

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doi = "10.1016/0014-5793(95)00412-3",

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T1 - Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation

AU - Abeyama, Kazuhiro

AU - Kawano, Kazunori

AU - Nakajima, Toshihiro

AU - Takasaki, Ikuko

AU - Kitajima, Isao

AU - Maruyama, Ikuro

PY - 1995/5/15

Y1 - 1995/5/15

N2 - The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF-κB) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.

AB - The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF-κB) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.

KW - Cell redox

KW - Differentiation

KW - Interleukin 6

KW - Ionizing radiation

KW - Nuclear factor κB

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U2 - 10.1016/0014-5793(95)00412-3

DO - 10.1016/0014-5793(95)00412-3

M3 - 学術論文

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AN - SCOPUS:0029070490

SN - 0014-5793

VL - 364

SP - 298

EP - 300

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation

Abstract

Keywords

ASJC Scopus subject areas

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