TY - JOUR
T1 - Ink jet three-dimensional digital fabrication for biological tissue manufacturing
T2 - Analysis of alginate microgel beads produced by ink jet droplets for three dimensional tissue fabrication
AU - Nakamura, Makoto
AU - Nishiyama, Yuichi
AU - Henmi, Chizuka
AU - Iwanaga, Shintaroh
AU - Nakagawa, Hidemoto
AU - Yamaguchi, Kumiko
AU - Akita, Keiichi
AU - Mochizuki, Shuichi
AU - Takiura, Koki
PY - 2008/11
Y1 - 2008/11
N2 - Ink jet technology has advantages such as high-resolution and a multicolor printing capability and has a good potential for computer-based three-dimensional (3D) fabrication. The authors have developed an ink jet 3D bioprinter to manufacture biologically viable 3D structures using living cells. They have developed an effective method for the fabrication of 3D hydrogel structures by using ink jet technology with a liquid aqueous gelating medium, which is essential in fabricating 3D structures with living cells. In the present study, they evaluated the feasibility of the ink jet approach for digital 3D biofabrication, analyzing the microgel beads produced by the ink jet droplets. The ink jet droplets of sodium alginate solution, which were ejected into CaCl2 solution, gelled to form microgel beads. The resulting beads were analyzed by means of image-based particle analysis to show that homogeneously sized microgel beads were effectively produced. Ink jet 3D biofabrication has a high potential for effective digital fabrication with such homogeneous microgel beads and will provide promising approaches for sophisticated computer assisted tissue engineering.
AB - Ink jet technology has advantages such as high-resolution and a multicolor printing capability and has a good potential for computer-based three-dimensional (3D) fabrication. The authors have developed an ink jet 3D bioprinter to manufacture biologically viable 3D structures using living cells. They have developed an effective method for the fabrication of 3D hydrogel structures by using ink jet technology with a liquid aqueous gelating medium, which is essential in fabricating 3D structures with living cells. In the present study, they evaluated the feasibility of the ink jet approach for digital 3D biofabrication, analyzing the microgel beads produced by the ink jet droplets. The ink jet droplets of sodium alginate solution, which were ejected into CaCl2 solution, gelled to form microgel beads. The resulting beads were analyzed by means of image-based particle analysis to show that homogeneously sized microgel beads were effectively produced. Ink jet 3D biofabrication has a high potential for effective digital fabrication with such homogeneous microgel beads and will provide promising approaches for sophisticated computer assisted tissue engineering.
UR - http://www.scopus.com/inward/record.url?scp=59549085365&partnerID=8YFLogxK
U2 - 10.2352/J.ImagingSci.Technol.(2008)52:6(060201)
DO - 10.2352/J.ImagingSci.Technol.(2008)52:6(060201)
M3 - 学術論文
AN - SCOPUS:59549085365
SN - 1062-3701
VL - 52
SP - 602011
EP - 602016
JO - Journal of Imaging Science and Technology
JF - Journal of Imaging Science and Technology
IS - 6
ER -