Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice

Qun Zhang; Tsugunobu Andoh; Mitsuhiro Konno; Jung Bum Lee; Masao Hattori; Yasushi Kuraishi

doi:10.1248/bpb.33.909

Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice

Qun Zhang, Tsugunobu Andoh, Mitsuhiro Konno, Jung Bum Lee, Masao Hattori, Yasushi Kuraishi^*

^*Corresponding author for this work

Plant Resource Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

In this study, the antipruritic effect of the methanol extract of Ganoderma lucidum (MEGL) was studied in mice. Oral administration of MEGL (10-1000mg/kg) produced a dose-dependent inhibition of scratching, an itch-related response, induced by intradermal 5-hydroxytryptamine (5-HT) (100nmol/site), α-methyl-5-HT (100nmol/site), and proteinase-activated receptor-2 (PAR₂)-activating peptide SLIGRL-NH₂ (50nmol/site). However, MEGL (100-1000mg/kg) did not inhibit the scratching induced by histamine (100nmol/site), substance P (100nmol/site), and compound 48/80 (10 μg/site). These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR₂ and 5-HT_2A receptors are the sites of its action.

Original language	English
Pages (from-to)	909-911
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	33
Issue number	5
DOIs	https://doi.org/10.1248/bpb.33.909
State	Published - 2010

Keywords

Ganoderma lucidum
Itch
Proteinase-activated receptor
Scratch
Serotonin

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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title = "Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice",

abstract = "In this study, the antipruritic effect of the methanol extract of Ganoderma lucidum (MEGL) was studied in mice. Oral administration of MEGL (10-1000mg/kg) produced a dose-dependent inhibition of scratching, an itch-related response, induced by intradermal 5-hydroxytryptamine (5-HT) (100nmol/site), α-methyl-5-HT (100nmol/site), and proteinase-activated receptor-2 (PAR2)-activating peptide SLIGRL-NH2 (50nmol/site). However, MEGL (100-1000mg/kg) did not inhibit the scratching induced by histamine (100nmol/site), substance P (100nmol/site), and compound 48/80 (10 μg/site). These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR2 and 5-HT2A receptors are the sites of its action.",

keywords = "Ganoderma lucidum, Itch, Proteinase-activated receptor, Scratch, Serotonin",

author = "Qun Zhang and Tsugunobu Andoh and Mitsuhiro Konno and Lee, {Jung Bum} and Masao Hattori and Yasushi Kuraishi",

year = "2010",

doi = "10.1248/bpb.33.909",

language = "英語",

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pages = "909--911",

journal = "Biological and Pharmaceutical Bulletin",

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T1 - Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice

AU - Zhang, Qun

AU - Andoh, Tsugunobu

AU - Konno, Mitsuhiro

AU - Lee, Jung Bum

AU - Hattori, Masao

AU - Kuraishi, Yasushi

PY - 2010

Y1 - 2010

N2 - In this study, the antipruritic effect of the methanol extract of Ganoderma lucidum (MEGL) was studied in mice. Oral administration of MEGL (10-1000mg/kg) produced a dose-dependent inhibition of scratching, an itch-related response, induced by intradermal 5-hydroxytryptamine (5-HT) (100nmol/site), α-methyl-5-HT (100nmol/site), and proteinase-activated receptor-2 (PAR2)-activating peptide SLIGRL-NH2 (50nmol/site). However, MEGL (100-1000mg/kg) did not inhibit the scratching induced by histamine (100nmol/site), substance P (100nmol/site), and compound 48/80 (10 μg/site). These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR2 and 5-HT2A receptors are the sites of its action.

AB - In this study, the antipruritic effect of the methanol extract of Ganoderma lucidum (MEGL) was studied in mice. Oral administration of MEGL (10-1000mg/kg) produced a dose-dependent inhibition of scratching, an itch-related response, induced by intradermal 5-hydroxytryptamine (5-HT) (100nmol/site), α-methyl-5-HT (100nmol/site), and proteinase-activated receptor-2 (PAR2)-activating peptide SLIGRL-NH2 (50nmol/site). However, MEGL (100-1000mg/kg) did not inhibit the scratching induced by histamine (100nmol/site), substance P (100nmol/site), and compound 48/80 (10 μg/site). These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR2 and 5-HT2A receptors are the sites of its action.

KW - Ganoderma lucidum

KW - Itch

KW - Proteinase-activated receptor

KW - Scratch

KW - Serotonin

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DO - 10.1248/bpb.33.909

M3 - 学術論文

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AN - SCOPUS:77952334928

SN - 0918-6158

VL - 33

SP - 909

EP - 911

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 5

ER -

Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice

Abstract

Keywords

ASJC Scopus subject areas

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