Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship

Suresh Awale; Yasuhiro Tezuka; Arjun H. Banskota; Shigetoshi Kadota

doi:10.1248/bpb.26.468

Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship

Suresh Awale, Yasuhiro Tezuka, Arjun H. Banskota, Shigetoshi Kadota^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.

Original language	English
Pages (from-to)	468-473
Number of pages	6
Journal	Biological and Pharmaceutical Bulletin
Volume	26
Issue number	4
DOIs	https://doi.org/10.1248/bpb.26.468
State	Published - 2003/04

Keywords

Nitric oxide (NO) inhibition
Orthosiphon stamineus
Staminane-type
Structure-activity relationship, diterpenes, isopimarane-type

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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abstract = "Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.",

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author = "Suresh Awale and Yasuhiro Tezuka and Banskota, {Arjun H.} and Shigetoshi Kadota",

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AU - Awale, Suresh

AU - Tezuka, Yasuhiro

AU - Banskota, Arjun H.

AU - Kadota, Shigetoshi

PY - 2003/4

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N2 - Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.

AB - Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.

KW - Nitric oxide (NO) inhibition

KW - Orthosiphon stamineus

KW - Staminane-type

KW - Structure-activity relationship, diterpenes, isopimarane-type

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M3 - 学術論文

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SN - 0918-6158

VL - 26

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Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship

Abstract

Keywords

ASJC Scopus subject areas

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