Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus

Jun Nishikawa; Hisashi Funada; Takako Miyazaki; Haruka Fujinami; Takayoshi Miyazono; Jun Murakami; Takahiko Kudo; Toshiro Sugiyama

doi:10.1007/s10156-011-0221-6

Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus

Jun Nishikawa, Hisashi Funada, Takako Miyazaki, Haruka Fujinami, Takayoshi Miyazono, Jun Murakami, Takahiko Kudo, Toshiro Sugiyama^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Infectious mononucleosis (IM) is a clinical syndrome caused by primary infection with Epstein-Barr virus (EBV) that is common in adolescents. In adults, particularly in elderly people, the clinical picture of IM tends to be atypical, often leading to a diagnostic challenge. Diagnosis is also complicated because infection with EBV can induce the synthesis of cross-reacting immunoglobulin M antibodies for other herpesviruses. We report an unusual case of infectious mononucleosis in a 34-yearold immunocompetent adult. Epidemiological studies indicate that the average age of primary EBV infection in developed countries is increasing. IM with atypical presentation will be a diagnostic challenge in the future as the number of EBV-naïve adults increases.

Original language	English
Pages (from-to)	686-688
Number of pages	3
Journal	Journal of Infection and Chemotherapy
Volume	17
Issue number	5
DOIs	https://doi.org/10.1007/s10156-011-0221-6
State	Published - 2011/10

Keywords

Cytomegalovirus
Epstein-Barr virus
Immunocompetent adult
Infectious mononucleosis

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10156-011-0221-6

Cite this

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title = "Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus",

abstract = "Infectious mononucleosis (IM) is a clinical syndrome caused by primary infection with Epstein-Barr virus (EBV) that is common in adolescents. In adults, particularly in elderly people, the clinical picture of IM tends to be atypical, often leading to a diagnostic challenge. Diagnosis is also complicated because infection with EBV can induce the synthesis of cross-reacting immunoglobulin M antibodies for other herpesviruses. We report an unusual case of infectious mononucleosis in a 34-yearold immunocompetent adult. Epidemiological studies indicate that the average age of primary EBV infection in developed countries is increasing. IM with atypical presentation will be a diagnostic challenge in the future as the number of EBV-na{\"i}ve adults increases.",

keywords = "Cytomegalovirus, Epstein-Barr virus, Immunocompetent adult, Infectious mononucleosis",

author = "Jun Nishikawa and Hisashi Funada and Takako Miyazaki and Haruka Fujinami and Takayoshi Miyazono and Jun Murakami and Takahiko Kudo and Toshiro Sugiyama",

year = "2011",

month = oct,

doi = "10.1007/s10156-011-0221-6",

language = "英語",

volume = "17",

pages = "686--688",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier B.V.",

number = "5",

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TY - JOUR

T1 - Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus

AU - Nishikawa, Jun

AU - Funada, Hisashi

AU - Miyazaki, Takako

AU - Fujinami, Haruka

AU - Miyazono, Takayoshi

AU - Murakami, Jun

AU - Kudo, Takahiko

AU - Sugiyama, Toshiro

PY - 2011/10

Y1 - 2011/10

N2 - Infectious mononucleosis (IM) is a clinical syndrome caused by primary infection with Epstein-Barr virus (EBV) that is common in adolescents. In adults, particularly in elderly people, the clinical picture of IM tends to be atypical, often leading to a diagnostic challenge. Diagnosis is also complicated because infection with EBV can induce the synthesis of cross-reacting immunoglobulin M antibodies for other herpesviruses. We report an unusual case of infectious mononucleosis in a 34-yearold immunocompetent adult. Epidemiological studies indicate that the average age of primary EBV infection in developed countries is increasing. IM with atypical presentation will be a diagnostic challenge in the future as the number of EBV-naïve adults increases.

AB - Infectious mononucleosis (IM) is a clinical syndrome caused by primary infection with Epstein-Barr virus (EBV) that is common in adolescents. In adults, particularly in elderly people, the clinical picture of IM tends to be atypical, often leading to a diagnostic challenge. Diagnosis is also complicated because infection with EBV can induce the synthesis of cross-reacting immunoglobulin M antibodies for other herpesviruses. We report an unusual case of infectious mononucleosis in a 34-yearold immunocompetent adult. Epidemiological studies indicate that the average age of primary EBV infection in developed countries is increasing. IM with atypical presentation will be a diagnostic challenge in the future as the number of EBV-naïve adults increases.

KW - Cytomegalovirus

KW - Epstein-Barr virus

KW - Immunocompetent adult

KW - Infectious mononucleosis

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U2 - 10.1007/s10156-011-0221-6

DO - 10.1007/s10156-011-0221-6

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AN - SCOPUS:84855424062

SN - 1341-321X

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SP - 686

EP - 688

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 5

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Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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