Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator

Minoru Narita; Satoshi Imai; Kousei Oe; Michiko Narita; Chiharu Kubota; Yoshinori Yajima; Mitsuaki Yamazaki; Tsutomu Suzuki

doi:10.1016/j.brainres.2004.04.027

Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator

Minoru Narita^*, Satoshi Imai, Kousei Oe, Michiko Narita^*, Chiharu Kubota, Yoshinori Yajima, Mitsuaki Yamazaki, Tsutomu Suzuki

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Here, we found that a single intrathecal (i.t.) administration of a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), induced pain-like behaviors in mice. Furthermore, i.t.-administered PDBu caused the increased c-fos-like immunoreactivity in the parafascicular nuclei (PF), amygdala and cingulate cortex (CG), but not hippocampus. These findings suggest that the stimulation of spinal PKC results in an enhancement of neuronal activity in the PF, amygdala and CG associated with hyperalgesia.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	Brain Research
Volume	1015
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.04.027
State	Published - 2004/07/23

Keywords

Brain
Hyperalgesia
Pain modulation: pharmacology
Protein kinase C
Sensory systems
Spinal cord
c-fos

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2004.04.027

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@article{02324eb9050946178f02743ccd8d5d39,

title = "Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator",

abstract = "Here, we found that a single intrathecal (i.t.) administration of a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), induced pain-like behaviors in mice. Furthermore, i.t.-administered PDBu caused the increased c-fos-like immunoreactivity in the parafascicular nuclei (PF), amygdala and cingulate cortex (CG), but not hippocampus. These findings suggest that the stimulation of spinal PKC results in an enhancement of neuronal activity in the PF, amygdala and CG associated with hyperalgesia.",

keywords = "Brain, Hyperalgesia, Pain modulation: pharmacology, Protein kinase C, Sensory systems, Spinal cord, c-fos",

author = "Minoru Narita and Satoshi Imai and Kousei Oe and Michiko Narita and Chiharu Kubota and Yoshinori Yajima and Mitsuaki Yamazaki and Tsutomu Suzuki",

note = "Funding Information: This work was supported in part by grants from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Culture, Sports, Science and Technology of Japan. ",

year = "2004",

month = jul,

day = "23",

doi = "10.1016/j.brainres.2004.04.027",

language = "英語",

volume = "1015",

pages = "189--193",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1-2",

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TY - JOUR

T1 - Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator

AU - Narita, Minoru

AU - Imai, Satoshi

AU - Oe, Kousei

AU - Narita, Michiko

AU - Kubota, Chiharu

AU - Yajima, Yoshinori

AU - Yamazaki, Mitsuaki

AU - Suzuki, Tsutomu

N1 - Funding Information: This work was supported in part by grants from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2004/7/23

Y1 - 2004/7/23

N2 - Here, we found that a single intrathecal (i.t.) administration of a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), induced pain-like behaviors in mice. Furthermore, i.t.-administered PDBu caused the increased c-fos-like immunoreactivity in the parafascicular nuclei (PF), amygdala and cingulate cortex (CG), but not hippocampus. These findings suggest that the stimulation of spinal PKC results in an enhancement of neuronal activity in the PF, amygdala and CG associated with hyperalgesia.

AB - Here, we found that a single intrathecal (i.t.) administration of a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), induced pain-like behaviors in mice. Furthermore, i.t.-administered PDBu caused the increased c-fos-like immunoreactivity in the parafascicular nuclei (PF), amygdala and cingulate cortex (CG), but not hippocampus. These findings suggest that the stimulation of spinal PKC results in an enhancement of neuronal activity in the PF, amygdala and CG associated with hyperalgesia.

KW - Brain

KW - Hyperalgesia

KW - Pain modulation: pharmacology

KW - Protein kinase C

KW - Sensory systems

KW - Spinal cord

KW - c-fos

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U2 - 10.1016/j.brainres.2004.04.027

DO - 10.1016/j.brainres.2004.04.027

M3 - 学術論文

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AN - SCOPUS:3042654998

SN - 0006-8993

VL - 1015

SP - 189

EP - 193

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator

Abstract

Keywords

ASJC Scopus subject areas

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