Improved synthesis of nigricanin

Hitoshi Abe; Takanori Nagai; Haruka Imai; Yoshikazu Horino

doi:10.1248/cpb.c17-00448

Improved synthesis of nigricanin

Hitoshi Abe^*, Takanori Nagai, Haruka Imai, Yoshikazu Horino

^*Corresponding author for this work

Applied Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented synthesis improved the sequence step number.

Original language	English
Pages (from-to)	1078-1080
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	65
Issue number	11
DOIs	https://doi.org/10.1248/cpb.c17-00448
State	Published - 2017

Keywords

Cannizzaro reaction
Ellagic acid
Russula nigricans
Ullmann coupling

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.c17-00448

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title = "Improved synthesis of nigricanin",

abstract = "An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented synthesis improved the sequence step number.",

keywords = "Cannizzaro reaction, Ellagic acid, Russula nigricans, Ullmann coupling",

author = "Hitoshi Abe and Takanori Nagai and Haruka Imai and Yoshikazu Horino",

note = "Publisher Copyright: {\textcopyright} 2017 The Pharmaceutical Society of Japan.",

year = "2017",

doi = "10.1248/cpb.c17-00448",

language = "英語",

volume = "65",

pages = "1078--1080",

journal = "Chemical and Pharmaceutical Bulletin",

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publisher = "Pharmaceutical Society of Japan",

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TY - JOUR

T1 - Improved synthesis of nigricanin

AU - Abe, Hitoshi

AU - Nagai, Takanori

AU - Imai, Haruka

AU - Horino, Yoshikazu

PY - 2017

Y1 - 2017

N2 - An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented synthesis improved the sequence step number.

AB - An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented synthesis improved the sequence step number.

KW - Cannizzaro reaction

KW - Ellagic acid

KW - Russula nigricans

KW - Ullmann coupling

UR - http://www.scopus.com/inward/record.url?scp=85033701332&partnerID=8YFLogxK

U2 - 10.1248/cpb.c17-00448

DO - 10.1248/cpb.c17-00448

M3 - 学術論文

C2 - 29093294

AN - SCOPUS:85033701332

SN - 0009-2363

VL - 65

SP - 1078

EP - 1080

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 11

ER -

Improved synthesis of nigricanin

Abstract

Keywords

ASJC Scopus subject areas

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